Differences in gut bacterial microbiota composition are associated with (A) degree of aeroallergen sensitisation; (B) lung function as measured by FEV1.

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Presentation transcript:

Differences in gut bacterial microbiota composition are associated with (A) degree of aeroallergen sensitisation; (B) lung function as measured by FEV1 %predicted (unweighted Unifrac); and (C) Principal component analysis of bacterial relative abundance dat... Differences in gut bacterial microbiota composition are associated with (A) degree of aeroallergen sensitisation; (B) lung function as measured by FEV1 %predicted (unweighted Unifrac); and (C) Principal component analysis of bacterial relative abundance data (Hellinger-transformed) of all available samples, with splines representing FEV1 %predicted values. (D) Differences in FEV1 %predicted correlate most strongly with gut bacterial compositional variation along principal component 2 (PC2 loading scores of paired asthmatic samples coloured by subject; repeated-measures correlation). FEV1, forced expiratory volume in 1 s; PC1, principal component 1; PC2, principal component 2. Lesa Begley et al. BMJ Open Resp Res 2018;5:e000324 ©2018 by British Thoracic Society