Preventing Bacterial Suicide: A Novel Toxin-Antitoxin Strategy

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing Jens Verbeeren, Elina H. Niemelä, Janne J. Turunen, Cindy.

Conserved Bacterial RNase YbeY Plays Key Roles in 70S Ribosome Quality Control and 16S rRNA Maturation Asha Ivy Jacob, Caroline Köhrer, Bryan William Davies,

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial- Mesenchymal Transition Min-Zu Wu, Ya-Ping Tsai, Muh-Hwa Yang, Chi-Hung Huang,

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

A View to a Kill: The Bacterial Type VI Secretion System Brian T. Ho, Tao G. Dong, John J. Mekalanos Cell Host & Microbe Volume 15, Issue 1, Pages 9-21.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

E3-Independent Monoubiquitination of Ubiquitin-Binding Proteins Daniela Hoeller, Christina-Maria Hecker, Sebastian Wagner, Vladimir Rogov, Volker Dötsch,

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Regulatory Subunits of Energy-Dependent Proteases

Tuberculosis: Hey There, Lonely Guy!

Inter-chromosomal Contact Properties in Live-Cell Imaging and in Hi-C

The DNA Damage Response: Ten Years After

Structural Insights into Riboswitch Control of the Biosynthesis of Queuosine, a Modified Nucleotide Found in the Anticodon of tRNA Mijeong Kang, Robert.

Volume 63, Issue 1, Pages 3-4 (July 2016)

Regulatory Subunits of Energy-Dependent Proteases

Engineering the End: DNA Processing at Human Telomeres

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

Skill Development in Graduate Education

B. Brett Finlay, Grant McFadden Cell

The Case of the Disappearing Drug Target

How To Choose a Good Scientific Problem

Triggering Selective Autophagy at the Right Place and the Right Time

A New Window onto Translational Repression by Bacterial sRNAs

P Bodies and the Control of mRNA Translation and Degradation

Jan Philipp Junker, Alexander van Oudenaarden Molecular Cell

Volume 46, Issue 5, Pages (June 2012)

Life after MOMP Molecular Cell

Joseph W. Briggs, Jonathan D. Dinman Molecular Cell

Eukaryotic Transcription Activation: Right on Target

Joseph W. Briggs, Jonathan D. Dinman Molecular Cell

Lucas T. Gray, Alan M. Weiner Molecular Cell

An Argonaute Protein Directs Nuclear Xrn2 Function

Hijacking the DNA Damage Response to Enhance Viral Replication: γ-Herpesvirus 68 orf36 Phosphorylates Histone H2AX Anyong Xie, Ralph Scully Molecular.

MicroRNAs and Viral Infection

Drugging Chromatin in Cancer: Recent Advances and Novel Approaches

Structural Insights into Riboswitch Control of the Biosynthesis of Queuosine, a Modified Nucleotide Found in the Anticodon of tRNA Mijeong Kang, Robert.

Volume 143, Issue 6, (December 2010)

Volume 36, Issue 2, Pages (October 2009)

Remarkable Functional Convergence: Alarmone ppGpp Mediates Persistence by Activating Type I and II Toxin-Antitoxins Kenn Gerdes, Etienne Maisonneuve

The Cell Biology of Genomes: Bringing the Double Helix to Life

A FIRE-y PAGE in the Computational Analysis of Cancer Profiles

Silencing the Transcriptome's Dark Matter: Mechanisms for Suppressing Translation of Intergenic Transcripts Kellie S. Bickel, David R. Morris Molecular.

The DNA Damage Response: Ten Years After

How To Choose a Good Scientific Problem

Volume 61, Issue 2, Pages (January 2016)

Chromatin Scanning by Dynamic Binding of Pioneer Factors

Chaos Controlled: Discovery of a Powerful Amyloid Inhibitor

Volume 25, Issue 2, Pages (January 2007)

Back to the Roots: Deep View into the Evolutionary History of ADP-Ribosylation Opened by the DNA-Targeting Toxin-Antitoxin Module DarTG Alexander Harms,

A New Window onto Translational Repression by Bacterial sRNAs

Eric Verdin, Melanie Ott Molecular Cell

Gene Regulation in the Postgenomic Era: Technology Takes the Wheel

Presentation transcript:

Preventing Bacterial Suicide: A Novel Toxin-Antitoxin Strategy Monica Markovski, Sue Wickner Molecular Cell Volume 52, Issue 5, Pages 611-612 (December 2013) DOI: 10.1016/j.molcel.2013.11.018 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 The SocAB System Is a New Class of Toxin-Antitoxin Modules (A) Unlike canonical toxin-antitoxin systems, the SocA antitoxin (purple) acts as a proteolytic adaptor for the degradation of SocB toxin (red) by the protease ClpXP (gray). (B) The five types of toxin-antitoxin systems are classified based on the mechanism of action the antitoxin (purple) employs to inactivate toxin (red) activity. AT, antitoxin; T, toxin. Molecular Cell 2013 52, 611-612DOI: (10.1016/j.molcel.2013.11.018) Copyright © 2013 Elsevier Inc. Terms and Conditions