CD3+/Tregs Ratio in Donor Grafts Is Linked to Acute Graft-versus-Host Disease and Immunologic Recovery after Allogeneic Peripheral Blood Stem Cell Transplantation

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Presentation transcript:

CD3+/Tregs Ratio in Donor Grafts Is Linked to Acute Graft-versus-Host Disease and Immunologic Recovery after Allogeneic Peripheral Blood Stem Cell Transplantation Domenico Pastore, Mario Delia, Anna Mestice, Paola Carluccio, Tommasina Perrone, Francesco Gaudio, Paola Curci, Antonella Russo Rossi, Alessandra Ricco, Giorgina Specchia Biology of Blood and Marrow Transplantation Volume 18, Issue 6, Pages 887-893 (June 2012) DOI: 10.1016/j.bbmt.2011.10.039 Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Correlation between gTregs and peripheral blood Tregs. Dots correspond to samples from patients in the second month correlated with the gTregs at the time of graft reinfusion. A significant positive correlation was seen between gTregs and peripheral blood Tregs, as shown by the trend line (r = 0.36; P = .003). Biology of Blood and Marrow Transplantation 2012 18, 887-893DOI: (10.1016/j.bbmt.2011.10.039) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Correlation between gCD3/Tregs R and peripheral blood Tregs. Dots correspond to samples from patients in the second month correlated with the gCD3/Tregs R at the time of graft reinfusion. A significant positive correlation was seen between cCD3/Tregs R and peripheral blood Tregs, as shown by the trend line (r = 0.38; P = .002). Biology of Blood and Marrow Transplantation 2012 18, 887-893DOI: (10.1016/j.bbmt.2011.10.039) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Median value of circulating peripheral blood Tregs in the LR and HR groups. Biology of Blood and Marrow Transplantation 2012 18, 887-893DOI: (10.1016/j.bbmt.2011.10.039) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Median value of circulating CMV-specific CD8+ T cells in the LR and HR groups. Biology of Blood and Marrow Transplantation 2012 18, 887-893DOI: (10.1016/j.bbmt.2011.10.039) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Median value of circulating peripheral blood Tregs in patients receiving rATG (rATG+) and those not receiving rATG (rATG−). Biology of Blood and Marrow Transplantation 2012 18, 887-893DOI: (10.1016/j.bbmt.2011.10.039) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 6 Median value of circulating CMV-specific CD8+ T cells in patients receiving rATG (rATG+) and those not receiving rATG (rATG−). Biology of Blood and Marrow Transplantation 2012 18, 887-893DOI: (10.1016/j.bbmt.2011.10.039) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions