Andras Khoor, MD, Jeffrey L. Myers, MD, Henry D

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Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Nodule Andras Khoor, MD, Jeffrey L. Myers, MD, Henry D. Tazelaar, MD, Stephen J. Swensen, MD Mayo Clinic Proceedings Volume 76, Issue 2, Pages 209-211 (February 2001) DOI: 10.4065/76.2.209 Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Photomicrographs. Top, Low magnification demonstrating a solitary nodule of pulmonary Langerhans cell histiocytosis. The periphery of the nodule shows an irregular interface with the adjacent alveolated lung parenchyma. The central portion of the nodule reveals a combination of inflammation and fibrosis (hematoxylin-eosin, original magnification ×2). Bottom, Higher power shows a combination of inflammation and fibrosis with numerous darkly staining eosinophils and clusters of Langerhans cells with folded nuclei (arrows) (hematoxylin-eosin, original magnification ×200). Inset, These cells were positive for S-100 protein and CD1a (immunoperoxidase for CD1a, original magnification ×400). Mayo Clinic Proceedings 2001 76, 209-211DOI: (10.4065/76.2.209) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions