Volume 86, Issue 2, Pages 286-293 (August 2014) Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation  Nadine Kaesler, Elke Magdeleyns, Marjolein Herfs, Thomas Schettgen, Vincent Brandenburg, Danilo Fliser, Cees Vermeer, Jürgen Floege, Georg Schlieper, Thilo Krüger  Kidney International  Volume 86, Issue 2, Pages 286-293 (August 2014) DOI: 10.1038/ki.2013.530 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Overview of the different treatment groups. Seven weeks of treatment contained a 2-week interphase without adenine supplementation. *Protein content was lowered to 2.5% in the 7-week groups (see Supplemetary Table S2 online). All diets contained 5mg/kg vitamin (Vit) K1 (except diet in group i). Kidney International 2014 86, 286-293DOI: (10.1038/ki.2013.530) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Undercarboxylated matrix Gla protein (ucMGP) measured in serum after 4 weeks of treatment. *P<0.05. Kidney International 2014 86, 286-293DOI: (10.1038/ki.2013.530) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 3 Hepatic vitamin K content. (a) Vitamin K1 measured in liver tissue after 7 weeks of diet; (b) MK4 measured in liver tissue after 7 weeks of diet. **P<0.01. Kidney International 2014 86, 286-293DOI: (10.1038/ki.2013.530) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 4 Quantification of undercarboxylated matrix Gla protein (ucMGP) staining in aortas after 7 weeks of treatment. *P<0.05. Kidney International 2014 86, 286-293DOI: (10.1038/ki.2013.530) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 5 The γ-glutamyl carboxylase (GGCX) activity. In kidneys after 4 (a) and 7 (b) weeks and in liver after 4 (c) and 7 (d) weeks (mean±s.d.). *P<0.05 and **P<0.01. Kidney International 2014 86, 286-293DOI: (10.1038/ki.2013.530) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 6 The γ-glutamyl carboxylase (GGCX) activity in aortas after 7 weeks (mean±s.d.) of treatment. *P<0.05. Kidney International 2014 86, 286-293DOI: (10.1038/ki.2013.530) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 7 The DT-diaphorase activity. In kidneys after 4 (a) and 7 (b) weeks and in liver after 4 (c) and 7 (d) weeks (mean±s.d.). *P<0.05. Kidney International 2014 86, 286-293DOI: (10.1038/ki.2013.530) Copyright © 2014 International Society of Nephrology Terms and Conditions