Severity of the cardiac impairment determines whether digitalis prolongs or reduces survival of rats with heart failure due to myocardial infarction

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Severity of the cardiac impairment determines whether digitalis prolongs or reduces survival of rats with heart failure due to myocardial infarction Alexandra A. dos Santos, Izo Helber, Ednei L. Antonio, Marcelo F. Franco, Paulo J.F. Tucci International Journal of Cardiology Volume 167, Issue 2, Pages 357-361 (July 2013) DOI: 10.1016/j.ijcard.2011.12.097 Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Kaplan–Meier curves comparing survival probability in female rats of Control and Digitoxin groups after myocardial infarction equal or larger than 37% (MI≥37%) and myocardial infarction smaller than 37% (MI<37%). International Journal of Cardiology 2013 167, 357-361DOI: (10.1016/j.ijcard.2011.12.097) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Kaplan–Meier curves comparing survival probability after myocardial infarction in female rats according to Doppler echocardiogram predictors of mortality. Survival estimates in the≥37% infarction digitoxin and placebo groups: A) FAC: fractional area change; B) E\A ratio; C) LVDD: left ventricle diastolic diameter; D) LVSD: left ventricle systolic diameter; E) LVSA: left ventricle systolic area. *P<0.05 (log rank test). International Journal of Cardiology 2013 167, 357-361DOI: (10.1016/j.ijcard.2011.12.097) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Kaplan–Meier curves comparing survival probability after myocardial infarction in female rats according to Doppler echocardiogram predictors of mortality. Survival estimates in the<37% infarction digitoxin and placebo groups: A) LVDD: left ventricle diastolic diameter; B) LVSD: left ventricle systolic diameter. *P<0.05 (log rank test). International Journal of Cardiology 2013 167, 357-361DOI: (10.1016/j.ijcard.2011.12.097) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions