D. Fletcher, V. Martinez  British Journal of Anaesthesia 

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Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta- analysis  D. Fletcher, V. Martinez  British Journal of Anaesthesia  Volume 112, Issue 6, Pages 991-1004 (June 2014) DOI: 10.1093/bja/aeu137 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 PRISMA flow chart detailing retrieved, excluded, assessed, and included trials. British Journal of Anaesthesia 2014 112, 991-1004DOI: (10.1093/bja/aeu137) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Forest plot for pain scores at rest at 1, 4 and 24 h. Pooled data analysis of the pain at rest in adults receiving intraoperative opioid vs control. CI, confidence interval. British Journal of Anaesthesia 2014 112, 991-1004DOI: (10.1093/bja/aeu137) Copyright © 2014 The Author(s) Terms and Conditions

Fig 3 Forest plots of morphine titration and morphine consumption at 24 h. Pooled data analysis of the cumulative opioid consumption in adults receiving intraoperative opioid vs control. CI, confidence interval. British Journal of Anaesthesia 2014 112, 991-1004DOI: (10.1093/bja/aeu137) Copyright © 2014 The Author(s) Terms and Conditions

Fig 4 Forest plot of primary (a) and secondary hyperalgesia (b). Pooled data analysis of the primary hyperalgesia (pain threshold near the wound) or secondary hyperalgesia (area around the wound) in adults receiving intraoperative opioid vs control. CI, confidence interval. British Journal of Anaesthesia 2014 112, 991-1004DOI: (10.1093/bja/aeu137) Copyright © 2014 The Author(s) Terms and Conditions

Fig 5 Funnel plot for pain at rest (a) and for morphine consumption at 24 h (b). Funnel plot to assess for publication bias. British Journal of Anaesthesia 2014 112, 991-1004DOI: (10.1093/bja/aeu137) Copyright © 2014 The Author(s) Terms and Conditions

Fig 6 Funnel plot for pain at rest (a) and for morphine consumption at 24 h (b). British Journal of Anaesthesia 2014 112, 991-1004DOI: (10.1093/bja/aeu137) Copyright © 2014 The Author(s) Terms and Conditions

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