International Journal of Cardiology

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International Journal of Cardiology Time-to-isolation guided titration of freeze duration in 3rd generation short-tip cryoballoon pulmonary vein isolation – Comparable clinical outcome and shorter procedure duration Alexander Pott, Christoph Kraft, Tilman Stephan, Kerstin Petscher, Wolfgang Rottbauer, Tillman Dahme International Journal of Cardiology Volume 255, Pages 80-84 (March 2018) DOI: 10.1016/j.ijcard.2017.11.039 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Flowchart depicting cryoenergy dosing depending on TTI (TTI group) or with a fixed ablation protocol (fixed group). Freeze cycles in the TTI group are varied depending on TTI. Occurrence of TTI in the different categories is indicated. AF - atrial fibrillation; PV - pulmonary vein; PVI – pulmonary vein isolation; TTI - time-to-isolation. International Journal of Cardiology 2018 255, 80-84DOI: (10.1016/j.ijcard.2017.11.039) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Kaplan-Meier curves indicating freedom from atrial arrhythmia recurrence during follow-up after cryoballoon pulmonary vein isolation with a fixed ablation protocol (fixed group) or a time-to-isolation-guided ablation protocol (TTI group). (A) Freedom from atrial arrhythmia recurrence off class I or class III antiarrhythmic drugs after a three-months blanking period. (B) Freedom from atrial fibrillation recurrence off class I or class III antiarrhythmic drugs after a three-months blanking period. International Journal of Cardiology 2018 255, 80-84DOI: (10.1016/j.ijcard.2017.11.039) Copyright © 2017 The Authors Terms and Conditions

Supplementary Fig. 3 Kaplan-Meier curves indicating freedom from atrial arrhythmia recurrence independent of class I/III antiarrhythmic drug therapy during follow-up after cryoballoon pulmonary vein isolation with a fixed ablation protocol (fixed group) or a time-to-isolation-guided ablation protocol (TTI group). (A) Freedom from atrial arrhythmia recurrence after a three-months blanking period. (B) Freedom from atrial fibrillation recurrence after a three-months blanking period. International Journal of Cardiology 2018 255, 80-84DOI: (10.1016/j.ijcard.2017.11.039) Copyright © 2017 The Authors Terms and Conditions