Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis W.Z. Wang, M.D., Ph.D., X.

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Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis W.Z. Wang, M.D., Ph.D., X. Guo, M.D., Ph.D., C. Duan, Ph.D., W.J. Ma, Ph.D., Y.G. Zhang, M.D., Ph.D., P. Xu, M.D., Ph.D., Z.Q. Gao, M.D., Z.F. Wang, Ph.D., H. Yan, M.D., Y.F. Zhang, M.D., Y.X. Yu, M.D., J.C. Chen, M.D., M.J. Lammi, Ph.D. Osteoarthritis and Cartilage Volume 17, Issue 1, Pages 83-90 (January 2009) DOI: 10.1016/j.joca.2008.05.008 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow chart showing the procedure for identifying genes with different expression levels in human cartilage of KBD and the normal. The terms “present,” and “absent” represent expression levels of the transcripts described in Materials and methods. Values are the mean±SD number and percentage of transcripts. See Materials and methods for details of the selection criteria. Osteoarthritis and Cartilage 2009 17, 83-90DOI: (10.1016/j.joca.2008.05.008) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Histogram showing levels of expression of eight selected genes, as measured by oligonucleotide array (solid bars: n=4) and real-time quantitative polymerase chain reaction (open bars: n=5).Values are the mean±SD (see Materials and methods for further details).*P<0.05, †P>0.01 for KBD vs the normal, by paired t-test. Osteoarthritis and Cartilage 2009 17, 83-90DOI: (10.1016/j.joca.2008.05.008) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions