Volume 67, Issue 2, Pages (February 2005)

Slides:

Advertisements

Similar presentations

Renal Stress Testing in the Assessment of Kidney Disease Lakhmir S. Chawla, Claudio Ronco Kidney International Reports Volume 1, Issue 1, Pages (May.

Advertisements

Pathophysiology of renal fluid retention

Volume 63, Issue 2, Pages (February 2003)

G1 kinases and transforming growth factor-β; signaling are associated with a growth pattern switch in diabetes-induced renal growth Hai-Chang Huang,

Volume 70, Issue 8, Pages (October 2006)

Volume 59, Issue 5, Pages (May 2001)

Quiz American Journal of Kidney Diseases

Cardiac remodeling and dysfunction in nephrotic syndrome

Volume 70, Issue 4, Pages (August 2006)

Renal Nerves, WNK4, Glucocorticoids, and Salt Transport

Volume 64, Issue 3, Pages (September 2003)

Volume 71, Issue 11, Pages (June 2007)

John M. Arthur, M.D.Ph.D., Shazia Shamim Kidney International

Volume 79, Issue 1, Pages (January 2011)

G protein β3 subunit C825T polymorphism in primary IgA nephropathy

TGF-β isoforms in renal fibrogenesis

Volume 81, Issue 4, Pages (February 2012)

Volume 64, Issue 6, Pages (December 2003)

Pathophysiology of renal fluid retention

Gentamicin causes endocytosis of Na/Pi cotransporter protein (NaPi-2)

Volume 54, Issue 1, Pages (July 1998)

Volume 60, Issue 5, Pages (November 2001)

Volume 66, Issue 2, Pages (August 2004)

Comorbidity and confounding in end-stage renal disease

Volume 65, Issue 5, Pages (May 2004)

Down-regulation of Na+ transporters and AQP2 is responsible for acyclovir-induced polyuria and hypophosphatemia Lúcia Andrade, Nancy A. Rebouças, Antonio.

Volume 70, Issue 4, Pages (August 2006)

Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion Lynda A. Frassetto, Eileen Nash,

Volume 70, Issue 11, Pages (December 2006)

Volume 125, Issue 2, Pages (August 2003)

Volume 60, Issue 3, Pages (September 2001)

Volume 61, Issue 6, Pages (June 2002)

17-β Estradiol attenuates streptozotocin-induced diabetes and regulates the expression of renal sodium transporters S. Riazi, C. Maric, C.A. Ecelbarger

Volume 63, Issue 2, Pages (February 2003)

Disorders of the epithelial sodium channel: Insights into the regulation of extracellular volume and blood pressure Principal discussant: John B. Stokes

Volume 70, Issue 7, Pages (October 2006)

Volume 53, Issue 5, Pages (May 1998)

Na+/H+ exchange activity and NHE-3 expression in renal tubules from the spontaneously hypertensive rat Michael S. Lapointe, Chhinder Sodhi, Atul Sahai,

The third World Kidney Day: Looking back and thinking forward

Volume 58, Issue 1, Pages (July 2000)

Volume 54, Issue 4, Pages (October 1998)

Volume 64, Issue 2, Pages (August 2003)

Volume 69, Issue 2, Pages (January 2006)

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Resistance of mTAL Na+-dependent transporters and collecting duct aquaporins to dehydration in 7-month-old rats Hassane Amlal, Catherine Wilke Kidney.

Volume 75, Issue 7, Pages (April 2009)

Rosiglitazone reverses tenofovir-induced nephrotoxicity

S. Susan Hedayati, Essam F. Elsayed, Robert F. Reilly

The pathophysiology of edema formation in the nephrotic syndrome

Volume 71, Issue 11, Pages (June 2007)

Latest findings in phosphate homeostasis

Neena Gupta, Sahar R. Tarif, Mouin Seikaly, Michel Baum, M.D.

Volume 69, Issue 1, Pages (January 2006)

Joel Z. Melnick, Patricia A. Preisig, Robert J. Alpern, Michel Baum

Véronique Vallet, Jean-Daniel Horisberger, Bernard C. Rossier

Irena Klodos, Mikael Esmann, Robert L. Post Kidney International

Is it the low-protein diet or simply the salt restriction?

Volume 70, Issue 8, Pages (October 2006)

Volume 53, Issue 4, Pages (April 1998)

Increased renal calcium and magnesium transporter abundance in streptozotocin- induced diabetes mellitus C-T. Lee, Y-H.H. Lien, L-W. Lai, J-B. Chen, C-R.

Volume 56, Issue 5, Pages (November 1999)

Aldosterone and potassium secretion by the cortical collecting duct

Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia S. Faroqui, M. Levi,

Volume 53, Issue 5, Pages (May 1998)

Volume 60, Issue 2, Pages (August 2001)

Volume 60, Issue 3, Pages (September 2001)

Molecular biology of distal nephron sodium transport mechanisms

Volume 59, Issue 1, Pages (January 2001)

Epidemiologic data of renal diseases from a single unit in China: Analysis based on 13,519 renal biopsies Lei-Shi Li, Zhi-Hong Liu Kidney International

Presentation transcript:

Volume 67, Issue 2, Pages 622-630 (February 2005) Sodium retention in cirrhotic rats is associated with increased renal abundance of sodium transporter proteins Patricia Fernandez-Llama, Shana Ageloff, Guillermo Fernandez-Varo, Josefa Ros, Xiaoyan Wang, Nuria Garra, Cristina Esteva-Font, Jose Ballarin, Pere Barcelo, Vicente Arroyo, John B. Stokes, Mark A. Knepper, Wladimiro Jimenez Kidney International Volume 67, Issue 2, Pages 622-630 (February 2005) DOI: 10.1111/j.1523-1755.2005.67118.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Representative data showing changes in α-, β-, and γ-epithelial sodium channel (ENaC) subunits abundance in renal cortices of cirrhotic kidneys vs. controls. (A) Immunoblots. (B) Summary of densitometry data presented as percent change for cirrhosis vs. control. Kidney International 2005 67, 622-630DOI: (10.1111/j.1523-1755.2005.67118.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Summary of densitometry data showing mRNA levels by ribonuclease protection assay for α-, β-, and γ-epithelial sodium channel (ENaC) of cirrhotic kidneys vs. controls. Kidney International 2005 67, 622-630DOI: (10.1111/j.1523-1755.2005.67118.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Representative data showing changes of the thiazide-sensitive sodium chloride cotransporter (NCC) abundance in renal cortices of cirrhotic kidneys vs. controls. (A) Immunoblots. (B) Summary of densitometry data presented as percent change for cirrhosis vs. control. Kidney International 2005 67, 622-630DOI: (10.1111/j.1523-1755.2005.67118.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Measurement of kidney thiazide-sensitive sodium chloride cotransporter (NCC) mRNA using ribonuclease protection assay. (A) Example of primary data. (B) Summary of densitometry for control vs. cirrhosis. Kidney International 2005 67, 622-630DOI: (10.1111/j.1523-1755.2005.67118.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 5 Representative data for pre-macula densa sodium transporter proteins type 3 sodium hydrogen exchanger (NHE3), type 2 sodium phosphate cotransporter (NaPi-2), and type 2 sodium potassium 2 chloride cotransporter (NKCC2) abundance in renal cortices of cirrhotic kidneys vs. controls. (A) Immunoblots. (B) Summary of densitometry data presented as percent change for cirrhosis vs. control. Kidney International 2005 67, 622-630DOI: (10.1111/j.1523-1755.2005.67118.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 6 Assessment of brush border vs. whole cortical type 3 sodium hydrogen exchanger (NHE3) and type 2 sodium phosphate cotransporter (NaPi-2) in control vs. cirrhotic rat kidneys. Left axis shows ratio of band densities for brush border to whole homogenate. Ratio was significantly elevated for NHE3 but not for NaPi-2. Kidney International 2005 67, 622-630DOI: (10.1111/j.1523-1755.2005.67118.x) Copyright © 2005 International Society of Nephrology Terms and Conditions