Diona L. Damian, Gary M. Halliday Journal of Investigative Dermatology

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Ultraviolet Radiation Induced Suppression of Mantoux Reactions in Humans Diona L. Damian, Gary M. Halliday Journal of Investigative Dermatology Volume 110, Issue 5, Pages 824-827 (May 1998) DOI: 10.1046/j.1523-1747.1998.00176.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 A dose response is seen for EI and the diameter of Mantoux reactions varying with the log of PPD dose. Twelve subjects, three doses of PPD per subject. Journal of Investigative Dermatology 1998 110, 824-827DOI: (10.1046/j.1523-1747.1998.00176.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Significant suppression of PPD induced erythema was seen with suberythemal doses of UV. The mean MED of the 17 subjects was 152 mJ UVB per cm2; 95 mJ thus corresponds to ≈0.7 of the mean MED, and 150 mJ corresponds to ≈1 MED (mean + SEM;*p < 0.001; compared with unirradiated site; paired two tailed Student’s t test). Journal of Investigative Dermatology 1998 110, 824-827DOI: (10.1046/j.1523-1747.1998.00176.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Ultraviolet induced immunosuppression of DTH to tuberculin PPD (Mantoux test). This subject displayed a 52% reduction in PPD induced erythema with a suberythemal dose of 95 mJ per cm2 per day for five consecutive days. In contrast, the diameter of induration at the irradiated sites was reduced by only 25% when compared with the Mantoux reaction of unirradiated skin (“no UV”). Journal of Investigative Dermatology 1998 110, 824-827DOI: (10.1046/j.1523-1747.1998.00176.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Acute, suberythemal UV radiation (5 d) resulted in greater immunosuppression of Mantoux induced erythema (EI) than chronic irradiation using the same daily dose for 4–5 wk. There was a trend towards greater suppression of Mantoux induced induration (ϕ) with the shorter protocol (mean + SEM; n = 6;**p < 0.01, *p < 0.05; irradiated sites compared with unirradiated control; paired two tailed Student’s t test). Journal of Investigative Dermatology 1998 110, 824-827DOI: (10.1046/j.1523-1747.1998.00176.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions