Cold ischemia–induced damage to vascular endothelium results in permeability alterations in transplanted lungs M.A. Hidalgo, MDa b, K.A. Shah, MRCPatha,

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Presentation transcript:

Cold ischemia–induced damage to vascular endothelium results in permeability alterations in transplanted lungs M.A. Hidalgo, MDa b, K.A. Shah, MRCPatha, B.J. Fuller, PhDb, C.J. Green, PhD, DSc(Med), FRCVS, FRCPath, FRCS(Hon), Acadn Ukr, AcadScia The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 4, Pages 1027-1035 (October 1996) DOI: 10.1016/S0022-5223(96)70104-6 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 A, Control: Normal rat lung tissue. B, Alveolar edema and congestion after 48 hours of storage and 5 minutes of revascularization. (Original magnifications ×63.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 A, Control: Normal rat lung tissue. B, Alveolar edema and congestion after 48 hours of storage and 5 minutes of revascularization. (Original magnifications ×63.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 A, Perivascular edema after 48 hours of storage in a nonreperfused specimen. B, Alveolar hemorrhage after 72 hours of storage and 24 hours of revascularization. (Original magnifications: A, ×40; B, ×63.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 A, Perivascular edema after 48 hours of storage in a nonreperfused specimen. B, Alveolar hemorrhage after 72 hours of storage and 24 hours of revascularization. (Original magnifications: A, ×40; B, ×63.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 A, Bronchial epithelial surface blebbing after 48 hours of storage. B, Totally restored bronchial epithelium after 24 hours of revascularization, which followed 48 hours of storage. (Original magnifications ×400.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 A, Bronchial epithelial surface blebbing after 48 hours of storage. B, Totally restored bronchial epithelium after 24 hours of revascularization, which followed 48 hours of storage. (Original magnifications ×400.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Electron micrographs of normal rat lung endothelium. The whole of the surface was covered with regularly shaped ECs in close contact with each other. (Original magnifications: A, ×1600; B, ×8000.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Electron micrographs of normal rat lung endothelium. The whole of the surface was covered with regularly shaped ECs in close contact with each other. (Original magnifications: A, ×1600; B, ×8000.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Electron micrographs of rat pulmonary arterial endothelium. A, Storage for 48 hours; B, storage for 72 hours and revascularization for 5 minutes. A small intercellular gap can be seen between two ECs (A), and a semidetached cell (B) exposes basal matrix. (Original magnifications ×8000.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Electron micrographs of rat pulmonary arterial endothelium. A, Storage for 48 hours; B, storage for 72 hours and revascularization for 5 minutes. A small intercellular gap can be seen between two ECs (A), and a semidetached cell (B) exposes basal matrix. (Original magnifications ×8000.) The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 6 Electron micrographs of rat pulmonary arterial endothelium stored for 48 hours, followed by 5 minutes (A) or 24 hours (B) of revascularization. An increased number of surface microvilli and membrane blebs can be identified on EC surfaces at high magnification (A, original magnification ×8000). Discontinuities and loose intercellular connections can be appreciated at lower magnification (B, original magnification ×1600). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 6 Electron micrographs of rat pulmonary arterial endothelium stored for 48 hours, followed by 5 minutes (A) or 24 hours (B) of revascularization. An increased number of surface microvilli and membrane blebs can be identified on EC surfaces at high magnification (A, original magnification ×8000). Discontinuities and loose intercellular connections can be appreciated at lower magnification (B, original magnification ×1600). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1027-1035DOI: (10.1016/S0022-5223(96)70104-6) Copyright © 1996 Mosby, Inc. Terms and Conditions