Interaction of apolipoprotein E gene polymorphisms on miscarriage risk in black and white American women Silvia Gamundi-Segura, M.Sc., Elena Torres-Perez,

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Interaction of apolipoprotein E gene polymorphisms on miscarriage risk in black and white American women Silvia Gamundi-Segura, M.Sc., Elena Torres-Perez, M.Sc., Alejandro Sanz-Paris, M.D., Jose M. Arbones-Mainar, Ph.D. Fertility and Sterility Volume 105, Issue 6, Pages 1554-1560.e1 (June 2016) DOI: 10.1016/j.fertnstert.2016.02.021 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Population age distribution by race. (A) Smoothed age distribution in the year 25 follow-up for black and white women (dashed and solid lines, respectively) and their respective medians (vertical lines). Density × 100 = percentage of women at that age. (B) Distribution of APOE phenotypes in black women. (C) Distribution of APOE phenotypes in white women. Fertility and Sterility 2016 105, 1554-1560.e1DOI: (10.1016/j.fertnstert.2016.02.021) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Cumulative miscarriage rates (Kaplan-Meier estimator) for the first miscarriage according to race and APOE phenotype in (A) 1,070 black women and (B) 1,070 white women. *Hazard ratio (APOE2 vs. APOE3) = 1.47 (95 CI%, 1.06–2.05). Fertility and Sterility 2016 105, 1554-1560.e1DOI: (10.1016/j.fertnstert.2016.02.021) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions