Primary Malignant Ependymoma of the Lung

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Presentation transcript:

Primary Malignant Ependymoma of the Lung THOMAS B. CROTTY, M.Sc., M.B., M.R.C.P.I. Mayo Clinic Proceedings Volume 67, Issue 4, Pages 373-378 (April 1992) DOI: 10.1016/S0025-6196(12)61555-9 Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Computed tomographic scans of thorax before (A) and after (B) administration of chemotherapy and radiation therapy for small-cell carcinoma in right upper lobe of lung. Subsequent scan (C) shows presence of new nodule, which was identified as a malignant ependymoma on pathologic examination. Mayo Clinic Proceedings 1992 67, 373-378DOI: (10.1016/S0025-6196(12)61555-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Photomicrograph of metastatic small-cell carcinoma within a supraclavicular lymph node. (Hematoxylin-eosin; original magnification, ×400.) Mayo Clinic Proceedings 1992 67, 373-378DOI: (10.1016/S0025-6196(12)61555-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 Computed tomographic scans of head of study patient, showing no abnormality at time of detection of pulmonary ependymoma (A) but large left-sided intracerebral hemorrhage 6 months later (B). Mayo Clinic Proceedings 1992 67, 373-378DOI: (10.1016/S0025-6196(12)61555-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 4 Photomicrograph of spindle cells and oval nuclei arranged in ill-defined fascicles. (Hematoxylin-eosin; original magnification, ×250.) Mayo Clinic Proceedings 1992 67, 373-378DOI: (10.1016/S0025-6196(12)61555-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 5 Photomicrograph of perivascular pseudorosette. Note fibrillary appearance of cytoplasm. (Hematoxylin-eosin; original magnification, ×250.) Mayo Clinic Proceedings 1992 67, 373-378DOI: (10.1016/S0025-6196(12)61555-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 6 Photomicrograph of pronounced pleomorphic and, occasionally, multinucleated cells. (Hematoxylin-eosin; original magnification, ×250.) Mayo Clinic Proceedings 1992 67, 373-378DOI: (10.1016/S0025-6196(12)61555-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 7 Photomicrograph of immunostaining with glial fibrillary acidic protein, demonstrating strong cytoplasmic reactivity (arrows). (Original magnification, ×400.) Mayo Clinic Proceedings 1992 67, 373-378DOI: (10.1016/S0025-6196(12)61555-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 8 Electron micrographs, showing cytoplasmic filaments (A) and intercellular junction (B, arrow). (Original magnification, ×21,000 and ×68,000, respectively.) Mayo Clinic Proceedings 1992 67, 373-378DOI: (10.1016/S0025-6196(12)61555-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions