Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal.

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Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk Chen Suo, PhD, Yajun Yang, PhD, Ziyu Yuan, MSc, Tiejun Zhang, PhD, Xiaorong Yang, PhD, Tao Qing, PhD, Pei Gao, MSc, Leming Shi, PhD, Min Fan, MSc, Hongwei Cheng, MD, Ming Lu, PhD, Li Jin, PhD, Xingdong Chen, PhD, Weimin Ye, PhD Journal of Thoracic Oncology Volume 14, Issue 4, Pages 712-725 (April 2019) DOI: 10.1016/j.jtho.2018.12.023 Copyright © 2019 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Association between ethanol oxidization rate (x axis) and acetaldehyde-metabolizing rate (y axis) and risk of esophageal squamous cell carcinoma in alcohol drinkers and non-alcohol drinkers, respectively. Boldface numbers in the blue and white rectangle regions represent ORs in the subgroups that are defined by rs671 and rs1042026 genotypes, where fast ethanol oxidization rate refers to rs1042026 (AG/GG), slow ethanol oxidization rate refers to rs1042026 (AA), fast acetaldehyde oxidization rate refers to rs671 (GG), and slow acetaldehyde oxidization rate refers to rs671 (AG). Non-alcohol drinkers who have a slow ethanol oxidization rate and fast acetaldehyde oxidization rate have the lowest risk and thus are used as the reference group. A, alanine; G, guanine. Journal of Thoracic Oncology 2019 14, 712-725DOI: (10.1016/j.jtho.2018.12.023) Copyright © 2019 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Association between esophageal squamous cell carcinoma and alcohol consumption under certain metabolic capacity of alcohol. (A) Analysis stratified by genotypes of rs671 and rs1042026. The subgroups are labeled and defined as follows: ethanol-fast, fast ethanol oxidization rate for rs1042026 genotype AG/GG; ethanol-slow, slow ethanol oxidization rate for rs1042026 genotype AA; ethanal-fast, fast ethanal-metabolizing rate for rs671 genotype GG; and ethanal-slow, slow ethanal-metabolizing rate for rs671 genotype AG. (B) Stratified analysis by genotypes of rs671 and ethanol-metabolizing enzyme abundance level (E-MEAL) score. The subgroups are labeled and defined as follows: ethanol-fast, fast ethanol oxidization rate for E-MEAL less than 1; ethanol-slow, slow ethanol oxidization rate for E-MEAL score of 1 or higher; ethanol-fast, fast ethanal-metabolizing rate for rs671 genotype GG; and ethanal-slow, slow ethanal-metabolizing rate for rs671 genotype AG. A, alanine; G, guanine. Journal of Thoracic Oncology 2019 14, 712-725DOI: (10.1016/j.jtho.2018.12.023) Copyright © 2019 International Association for the Study of Lung Cancer Terms and Conditions