Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early- Onset Chronic Obstructive Pulmonary Disease Edwin K. Silverman, Lyle.

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Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early- Onset Chronic Obstructive Pulmonary Disease Edwin K. Silverman, Lyle J. Palmer, Jonathan D. Mosley, Matthew Barth, Jody M. Senter, Alison Brown, Jeffrey M. Drazen, David J. Kwiatkowski, Harold A. Chapman, Edward J. Campbell, Michael A. Province, D.C. Rao, John J. Reilly, Leo C. Ginns, Frank E. Speizer, Scott T. Weiss The American Journal of Human Genetics Volume 70, Issue 5, Pages 1229-1239 (May 2002) DOI: 10.1086/340316 Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 1 Multipoint variance-component linkage analysis of all 22 autosomes in pedigrees with early-onset COPD. Results of linkage analysis are presented for FEV1, FEV1/FVC, and FVC, with adjustment for relevant covariates. Genetic distance (in cM), from version 10 of the Marshfield map, is plotted against variance-component LOD score. Significant linkage was demonstrated for FEV1/FVC, on chromosome 2 (LOD score 4.12). The American Journal of Human Genetics 2002 70, 1229-1239DOI: (10.1086/340316) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 1 Multipoint variance-component linkage analysis of all 22 autosomes in pedigrees with early-onset COPD. Results of linkage analysis are presented for FEV1, FEV1/FVC, and FVC, with adjustment for relevant covariates. Genetic distance (in cM), from version 10 of the Marshfield map, is plotted against variance-component LOD score. Significant linkage was demonstrated for FEV1/FVC, on chromosome 2 (LOD score 4.12). The American Journal of Human Genetics 2002 70, 1229-1239DOI: (10.1086/340316) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 2 Multipoint variance-component linkage analysis of chromosome 12, including STR markers from the initial genomewide scan, as well as 12 additional markers. Genetic distance (in cM), from version 10 of the Marshfield map, is plotted against the multipoint variance-component LOD score for FEV1, FEV1/FVC, and FVC. For FEV1, a maximum LOD score of 2.43 was observed at 37 cM. The American Journal of Human Genetics 2002 70, 1229-1239DOI: (10.1086/340316) Copyright © 2002 The American Society of Human Genetics Terms and Conditions