Angiotensin-converting Enzyme Inhibitors and Outcomes in Heart Failure and Preserved Ejection Fraction Marjan Mujib, MD, MPH, Kanan Patel, MBBS, MPH,

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Angiotensin-converting Enzyme Inhibitors and Outcomes in Heart Failure and Preserved Ejection Fraction Marjan Mujib, MD, MPH, Kanan Patel, MBBS, MPH, Gregg C. Fonarow, MD, Dalane W. Kitzman, MD, Yan Zhang, MS, MSPH, Inmaculada B. Aban, PhD, O. James Ekundayo, MD, DrPH, Thomas E. Love, PhD, Meredith L. Kilgore, PhD, Richard M. Allman, MD, Mihai Gheorghiade, MD, Ali Ahmed, MD, MPH The American Journal of Medicine Volume 126, Issue 5, Pages 401-410 (May 2013) DOI: 10.1016/j.amjmed.2013.01.004 Copyright © 2013 Terms and Conditions

Figure 1 Flow chart displaying assembly of inception cohort of matched patients with heart failure and preserved ejection fraction. ACE = angiotensin-converting enzyme; OPTIMIZE-HF = Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure. The American Journal of Medicine 2013 126, 401-410DOI: (10.1016/j.amjmed.2013.01.004) Copyright © 2013 Terms and Conditions

Figure 2 Love plot displaying absolute standardized differences comparing 114* baseline characteristics between older patients with heart failure and preserved ejection fraction, receiving a new discharge prescription of ACE inhibitors, before and after propensity score matching. A = admission; D = discharge; H = in-hospital; Hx = medical history; PF = precipitating factor. *Four regions entered as single categorical variable in the model. The American Journal of Medicine 2013 126, 401-410DOI: (10.1016/j.amjmed.2013.01.004) Copyright © 2013 Terms and Conditions

Figure 3 Kaplan-Meier plot for primary composite end point of all-cause mortality or heart failure hospitalization in a propensity-matched inception cohort of older patients with heart failure and preserved ejection fraction receiving and not receiving a new discharge prescription for ACE inhibitors. ACE = angiotensin-converting enzyme; CI = confidence interval; HR = hazard ratio. The American Journal of Medicine 2013 126, 401-410DOI: (10.1016/j.amjmed.2013.01.004) Copyright © 2013 Terms and Conditions

Figure 4 Association of a new discharge prescription of ACE inhibitors with primary composite end point of all-cause mortality or heart failure hospitalization in subgroups of propensity-matched inception cohort of older patients with heart failure and preserved ejection fraction. ACE = angiotensin-converting enzyme; CI = confidence interval; GFR = glomerular filtration rate. The American Journal of Medicine 2013 126, 401-410DOI: (10.1016/j.amjmed.2013.01.004) Copyright © 2013 Terms and Conditions