Sensory-Motor Circuits: Hox Genes Get in Touch

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Presentation transcript:

Sensory-Motor Circuits: Hox Genes Get in Touch Polyxeni Philippidou, Jeremy S. Dasen Neuron Volume 88, Issue 3, Pages 437-440 (November 2015) DOI: 10.1016/j.neuron.2015.10.035 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Hox Genes Govern the Assembly of a Touch-Reflex Circuit in C. elegans (A) Summary of defects in TRN development in indicated mutant and transgenic lines. Deletion of the posterior Hox gene egl-5 results in a PLM to ALM transformation, including cell body displacement (black arrowhead), while egl-5 overexpression imposes a PLM fate on ALM neurons (white arrowhead). Rfip-1 mutants show shortening of the posterior PLM neurite, similar to egl-5 deletion, but cell body position is unaffected. A partial list of differentially expressed genes in ALM and PLM is shown on the right. (B) Genetic interactions between Hox, Hox cofactors, and target effectors during PLM differentiation. (C) Diagram of circuits controlling forward and reverse movement in response to posterior and anterior touch respectively. PLM to PVC functional connectivity requires egl-5. SN, sensory neuron; IN, interneuron; MN, motor neuron. Neuron 2015 88, 437-440DOI: (10.1016/j.neuron.2015.10.035) Copyright © 2015 Elsevier Inc. Terms and Conditions