F. Dell'Accio Osteoarthritis and Cartilage

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Pharmacological blockade of the WNT-beta-catenin signaling: a possible first-in-kind DMOAD F. Dell'Accio Osteoarthritis and Cartilage Volume 26, Issue 1, Pages 4-6 (January 2018) DOI: 10.1016/j.joca.2017.10.014 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Inflammatory and mechanical stimuli activate canonical WNT signaling in cartilage. Controlled and transient activation ensures that homeostatic events take place and supports stem cell renewal. Excessive activation leads to osteoarthritis. Osteoarthritis and Cartilage 2018 26, 4-6DOI: (10.1016/j.joca.2017.10.014) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions