Cyclic changes in expression of mRNA of vascular endothelial growth factor, its receptors Flt-1 and KDR/Flk-1, and Ets-1 in human corpora lutea Toshiaki.

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Cyclic changes in expression of mRNA of vascular endothelial growth factor, its receptors Flt-1 and KDR/Flk-1, and Ets-1 in human corpora lutea Toshiaki Endo, M.D., Yoshimitsu Kitajima, M.D., Akira Nishikawa, M.D., Kengo Manase, M.D., Masabumi Shibuya, M.D., Ryuichi Kudo, M.D. Fertility and Sterility Volume 76, Issue 4, Pages 762-768 (October 2001) DOI: 10.1016/S0015-0282(01)02012-X

FIGURE 1 (A), Northern blot analysis of expression of mRNA of vascular endothelial growth factor (VEGF), KDR/Flk-1, Flt-1, and Ets-1 in human corpora lutea. Total RNA was extracted from luteal tissues of five patients in the early luteal phase (ELP), five in the mid-luteal phase (MLP), and five in the late luteal phase (LLP). Samples were transferred onto nylon membranes and hybridized with 32P-labeled cDNA probes of human VEGF, Flt-1, KDR/Flk-1 and Ets-1. L-38 was the control. (B), Density mRNA signals of VEGF, Flt-1, KDR/Flk-1, and Ets-1. All densities were normalized against the density of the L38 band. The density of each signal in the early luteal phase was the a control. ∗P<.05 vs. density in the early luteal phase or mid-luteal phase. Endo.mRNA of VEGF and its receptors.Fertil Steril 2001. Fertility and Sterility 2001 76, 762-768DOI: (10.1016/S0015-0282(01)02012-X)

FIGURE 2 Immunohistochemical localization of VEGF, Flt-1, and KDR/Flk-1 in human corpus luteum in the early luteal phase, mid-luteal phase, and late luteal phase. (A), Immunostaining for VEGF in the early luteal phase. (B), Immunostaining for VEGF in the mid-luteal phase. (C), Immunostaining for VEGF in the late luteal phase. (D), Immunostaining for Flt-1 in the early luteal phase. (E), Immunostaining for Flt-1 in the mid-luteal phase. (F), Immunostaining for Flt-1 in the late luteal phase. (G) Immunostaining for KDR/Flk-1 in the early luteal phase. (H), Immunostaining for KDR/Flk-1 in the mid-luteal phase. (I), Immunostaining for KDR/Flk-1 in the late luteal phase. GL, granulosa lutein cell; TL, thecal lutein cell; DL, degenerated corpus luteum. Arrowheads indicate endothelial cells. Magnification, ×200. Endo.mRNA of VEGF and its receptors.Fertil Steril 2001. Fertility and Sterility 2001 76, 762-768DOI: (10.1016/S0015-0282(01)02012-X)