Hiroyuki Hirano, Eiji Takahashi, Katsuhiko Doi, Yoshihiro Watanabe

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Role of intracellular calcium in fatigue in single skeletal muscle fibers isolated from the rat Hiroyuki Hirano, Eiji Takahashi, Katsuhiko Doi, Yoshihiro Watanabe Pathophysiology Volume 6, Issue 4, Pages 211-216 (February 2000) DOI: 10.1016/S0928-4680(99)00029-2

Fig. 1 The relationship between magnitude of tetanic stimulation and tension developed in isolated perfused single muscle fibers. Pathophysiology 2000 6, 211-216DOI: (10.1016/S0928-4680(99)00029-2)

Fig. 2 The relationship between pulse frequency during tetanic stimulation and time required for development of fatigue (50% reduction in tetanic force at a particular frequency of stimulation). Pathophysiology 2000 6, 211-216DOI: (10.1016/S0928-4680(99)00029-2)

Fig. 3 The relationship between the ability of the muscle fibers to develop force when tetanically stimulated at 100 Hz before and after development of fatigue with different pulse frequency. Open and closed circles represent the 100 Hz force in control and fatigued fibers. Pathophysiology 2000 6, 211-216DOI: (10.1016/S0928-4680(99)00029-2)

Fig. 4 Comparisons of time required for the developed tension to fall to 50% of the 100 Hz force response after cessation of tetanic stimulation (RT50). Pathophysiology 2000 6, 211-216DOI: (10.1016/S0928-4680(99)00029-2)

Fig. 5 Representative data of the changes in [Ca2+]i and the 100 Hz force response before and after induction of fatigue. Fatigue was induced by repeated trains of 100 Hz tetanic stimuli. Pathophysiology 2000 6, 211-216DOI: (10.1016/S0928-4680(99)00029-2)

Fig. 6 Representative data demonstrating changes in [Ca2+]i and the 100 Hz force response before and after induction of fatigue. Fatigue was induced by repeated trains of 30 Hz tetanic stimuli. Pathophysiology 2000 6, 211-216DOI: (10.1016/S0928-4680(99)00029-2)