Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria S.D. Thorpe, S. Gambassi, R.

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Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria S.D. Thorpe, S. Gambassi, R. Patel, A. Santucci, M.M. Knight Osteoarthritis and Cartilage Volume 24, Pages S174-S175 (April 2016) DOI: 10.1016/j.joca.2016.01.343 Copyright © 2016 Terms and Conditions

Fig. 1. A. Representative primary cilia staining. B Fig. 1. A. Representative primary cilia staining. B. Violin plot of cilia length. Black lines indicate median and interquartile range. ***: p < 0.001. C. Representative super resolution structured illumination microscopy of ARL13b on cilia membrane. Line indicates profile position and arrow indicates distal tip of cilium. Osteoarthritis and Cartilage 2016 24, S174-S175DOI: (10.1016/j.joca.2016.01.343) Copyright © 2016 Terms and Conditions

Fig. 2. Aggrecan and collagen 2 gene expression relative to 18sRNA Fig. 2. Aggrecan and collagen 2 gene expression relative to 18sRNA. **: p < 0.01. Osteoarthritis and Cartilage 2016 24, S174-S175DOI: (10.1016/j.joca.2016.01.343) Copyright © 2016 Terms and Conditions

Fig. 3. A. Representative primary cilia immunofluorescent staining with LiCl treatment. B. Violin plot of cilia length. ***: p < 0.001; a: p < 0.001 vs. Healthy; b: p < 0.001 vs. AKU. Osteoarthritis and Cartilage 2016 24, S174-S175DOI: (10.1016/j.joca.2016.01.343) Copyright © 2016 Terms and Conditions