The Association of Lipid-Modifying Medications With Mortality in Patients on Long-Term Peritoneal Dialysis Alexander S. Goldfarb-Rumyantzev, MD, PhD,

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Presentation transcript:

The Association of Lipid-Modifying Medications With Mortality in Patients on Long-Term Peritoneal Dialysis Alexander S. Goldfarb-Rumyantzev, MD, PhD, Arsalan N. Habib, MD, Bradley C. Baird, MS, MStat, Lev L. Barenbaum, PhD, Alfred K. Cheung, MD American Journal of Kidney Diseases Volume 50, Issue 5, Pages 791-802 (November 2007) DOI: 10.1053/j.ajkd.2007.07.023 Copyright © 2007 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Flow chart describing study subject selection from the US Renal Data System (USRDS) Dialysis Morbidity and Mortality (DMMS) Wave 2 file. American Journal of Kidney Diseases 2007 50, 791-802DOI: (10.1053/j.ajkd.2007.07.023) Copyright © 2007 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Kaplan-Meier curves show the association between use of lipid-modifying medications and (A) all-cause and (B) cardiovascular mortality. American Journal of Kidney Diseases 2007 50, 791-802DOI: (10.1053/j.ajkd.2007.07.023) Copyright © 2007 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Adjusted hazard ratios for all-cause mortality associated with the use of lipid-modifying medications in subgroups of patients defined by serum total cholesterol level. The plot suggests an incremental increase in the benefit of using lipid-modifying medications with increasing cholesterol levels. To convert total cholesterol in mg/dL to mmol/L, multiply by 0.0259. American Journal of Kidney Diseases 2007 50, 791-802DOI: (10.1053/j.ajkd.2007.07.023) Copyright © 2007 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Adjusted hazard ratios for all-cause (filled bars) and cardiovascular (striped bars) mortality associated with use of lipid-modifying medications in the entire study population and the diabetic subgroup. *Statistically significant (P < 0.05) difference compared with patients not using these medications (open bar). American Journal of Kidney Diseases 2007 50, 791-802DOI: (10.1053/j.ajkd.2007.07.023) Copyright © 2007 National Kidney Foundation, Inc. Terms and Conditions