Ischemic preconditioning with opening of mitochondrial adenosine triphosphate– sensitive potassium channels or Na+/H+ exchange inhibition: Which is the.

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Presentation transcript:

Ischemic preconditioning with opening of mitochondrial adenosine triphosphate– sensitive potassium channels or Na+/H+ exchange inhibition: Which is the best protective strategy for heart transplants? Egidijus Kevelaitis, MD, PhD, Abdeslam Oubénaissa, MD, PhD, Christian Mouas, Jacqueline Peynet, MD, Philippe Menasché, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 121, Issue 1, Pages 155-162 (January 2001) DOI: 10.1067/mtc.2001.111417 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Left ventricular stiffness. The pressure-volume curves were obtained at baseline (before cardiac arrest) and after 60 minutes of reperfusion. Baseline data are expressed as a pooled group average. All values are means ± SEM. PC, Preconditioning. *P = .024 ischemic preconditioning versus control; **P < .001 ischemic preconditioning and cariporide (combined) versus control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 155-162DOI: (10.1067/mtc.2001.111417) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Total creatine kinase leakage during the initial 15 minutes of reperfusion. All values are means ± SD. PC, Preconditioning; A/S, arrest-storage; R, reperfusion; C, combined. *P = .029 versus control; **P = .004 versus control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 155-162DOI: (10.1067/mtc.2001.111417) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Endothelium-dependent coronary flow response to 5-HT (10–7 mol/L). All values are means ± SD. CF, Coronary flow; PC, preconditioning. *P < .001 versus preischemia and baseline; **P < .01 versus reperfusion and baseline (paired 2-tailed t tests); #P = .034 versus control group, reperfusion, and baseline (Student-Newman-Keuls test). The Journal of Thoracic and Cardiovascular Surgery 2001 121, 155-162DOI: (10.1067/mtc.2001.111417) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions