Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies

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Presentation transcript:

Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies Adnan Custovic, MD, PhD, Janet Rothers, MS, Debbie Stern, MS, Angela Simpson, MD, PhD, Ashley Woodcock, MD, Anne L. Wright, PhD, Nicolaos C. Nicolaou, MD, Jenny Hankinson, BSc, Marilyn Halonen, PhD, Fernando D. Martinez, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 2, Pages 390-397.e9 (February 2011) DOI: 10.1016/j.jaci.2010.10.050 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Percentage of children with allergic sensitization (assessed by SPT or specific IgE measurement [IgE]) by TLR2/–16934 genotype and day care attendance in early childhood. A, MAAS. B, IIS. Journal of Allergy and Clinical Immunology 2011 127, 390-397.e9DOI: (10.1016/j.jaci.2010.10.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Percentage of children with atopic wheeze by TLR2/–16934 genotype and day care attendance in early childhood; atopy was assessed by SPT or specific IgE measurement (IgE). A, MAAS. B, IIS. Journal of Allergy and Clinical Immunology 2011 127, 390-397.e9DOI: (10.1016/j.jaci.2010.10.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Percentage of children with BHR to EVH challenge at age 5 years by TLR2/–16934 genotype and day care attendance in MAAS. Journal of Allergy and Clinical Immunology 2011 127, 390-397.e9DOI: (10.1016/j.jaci.2010.10.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Percentage of children with allergic sensitization (assessed by specific IgE measurement) by TLR2/–16934 genotype and day care attendance in early childhood in MAAS. Journal of Allergy and Clinical Immunology 2011 127, 390-397.e9DOI: (10.1016/j.jaci.2010.10.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Percentage of children with current wheeze by TLR2/–16934 genotype and day care attendance in early childhood in MAAS. Journal of Allergy and Clinical Immunology 2011 127, 390-397.e9DOI: (10.1016/j.jaci.2010.10.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Percentage of children with current wheeze by TLR2/–16934 genotype and day care attendance in early childhood in IIS. Journal of Allergy and Clinical Immunology 2011 127, 390-397.e9DOI: (10.1016/j.jaci.2010.10.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Percentage of children with atopic wheeze (sensitization assessed by specific IgE measurement) by TLR2/–16934 genotype and day care attendance in early childhood in MAAS. Journal of Allergy and Clinical Immunology 2011 127, 390-397.e9DOI: (10.1016/j.jaci.2010.10.050) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions