This month in Gastroenterology Eugene B. Chang  Gastroenterology  Volume 127, Issue 6, Pages 1653-1655 (December 2004) DOI: 10.1053/j.gastro.2004.10.015 Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 1 The Receiver Operator Characteristic Curve is shown for the performance of the algorithm combining serum markers for discriminating between Scheuer fibrosis stages 0, 1, 2 versus 3, 4 in the validation sample set assessed by Pathologist A. Gastroenterology 2004 127, 1653-1655DOI: (10.1053/j.gastro.2004.10.015) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 2 Morphology of tissues taken at various distances from the site of resection 5 hours after surgery. Panels A–D show light micrographs of cross-sections through the tunica muscularis at distances 5.0–0 cm from the resection site. Close to the resection site both muscle layers appeared disrupted (C; 1 cm oral and D; the site of resection) and there was infiltration of the tissue by neutrophils (arrowheads in C and D). CM and LM indicate the circular and longitudinal muscle layers respectively. Panels E–H show Kit-like immunoreactivity (Kit-LI) in muscles samples taken at various distances from the site of resection site (5.0–0 cm respectively). Kit-LI decreased at the level of the myenteric and deep muscular plexuses (not shown) in muscles close to the site of resection (Panel H). Panels I–K show electron micrographs of the myenteric plexus region at 5 cm, 2–3 cm, and within 0.5 cm of the site of resection, respectively. Typical ICC-MY were observed at 5 cm and 2–3 cm from the site of resection (arrows). However, near the site of resection, ICC-MY were not observed. Scale bar in panel D represents 50 μmol/L and applies to panels A–D. Scale bar in panel H represents 50 μmol and applies to panels E–H and scale bars in panels I–K represent 1.0 μmol/L. Gastroenterology 2004 127, 1653-1655DOI: (10.1053/j.gastro.2004.10.015) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 3 Liver sections after staining with hematoxylin and eosin. Mice were challenged with acetaminophen (500 mg/kg) with or without anti-NK1.1 treatment. Livers were harvested at 24 hours later and prepared for histology. Necrotic areas are indicated by arrows. Gastroenterology 2004 127, 1653-1655DOI: (10.1053/j.gastro.2004.10.015) Copyright © 2004 American Gastroenterological Association Terms and Conditions