Crystals in podocytes: an unusual manifestation of systemic disease Jolanta Kowalewska, MD, Robert C Tomford, MD, Charles E Alpers, MD  American Journal of Kidney Diseases  Volume 42, Issue 3, Pages 605-611 (September 2003) DOI: 10.1016/S0272-6386(03)00794-7 Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 1 Representative glomerulus with plump epithelialcells containing intracytoplasmic crystalline inclusions. (Methenamine silver—periodic acid-Schiff [Jones] stain; original magnification ×1,000.) American Journal of Kidney Diseases 2003 42, 605-611DOI: (10.1016/S0272-6386(03)00794-7) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 2 Accumulations of crystalline material within renal interstitial cells. (Methylene blue epon section; original magnification ×400.) American Journal of Kidney Diseases 2003 42, 605-611DOI: (10.1016/S0272-6386(03)00794-7) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 3 Perirenal connective tissue infiltrated by crystal-containing mononuclear cells. (Methylene blue epon section; original magnification ×400.) American Journal of Kidney Diseases 2003 42, 605-611DOI: (10.1016/S0272-6386(03)00794-7) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 4 Electron micrograph shows glomerular visceral epithelial cells containing abundant rectangular and rod-shaped crystalline inclusions. (Original magnification ×2,400.) American Journal of Kidney Diseases 2003 42, 605-611DOI: (10.1016/S0272-6386(03)00794-7) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 5 High-magnification electron micrograph shows a podocyte containing crystalline inclusions. (Original magnification ×12,000.) American Journal of Kidney Diseases 2003 42, 605-611DOI: (10.1016/S0272-6386(03)00794-7) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 6 Immunohistochemistry staining for κ light chains shows positivity in the distribution of crystals within the cytoplasm of renal interstitial cells. There was no comparable staining for λ light chains on a sequential tissue section. (Original magnification ×200.) American Journal of Kidney Diseases 2003 42, 605-611DOI: (10.1016/S0272-6386(03)00794-7) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 7 Immunohistochemistry staining for CD68 shows reactivity of the crystal-containing renal interstitial cells. (Original magnification ×200.) American Journal of Kidney Diseases 2003 42, 605-611DOI: (10.1016/S0272-6386(03)00794-7) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions