Time course of inflammation, tissue damage and resolution of pneumonia: potential adjuvant therapies. Time course of inflammation, tissue damage and resolution.

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Presentation transcript:

Time course of inflammation, tissue damage and resolution of pneumonia: potential adjuvant therapies. Time course of inflammation, tissue damage and resolution of pneumonia: potential adjuvant therapies. Subsequent to ligand binding pathogen recognition receptors initiate the host inflammatory response, including cytokine production, recruitment of leukocytes and activation of the complement system, thereby leading to elimination of the pathogen and infected cells. However, immune overactivation may lead to tissue damage and barrier failure. From the beginning of the inflammatory response, pulmonary repair and resolution processes are initiated to balance damage and healing of the tissue, ideally resulting in restoration of the original condition (restitutio ad integrum). Potential adjuvant therapies target different processes during pneumonia, thereby potentially exerting beneficial functions in addition to antibiotic treatment. DAMPs: danger-associated molecular patterns; PRRs: pattern recognition receptors; GM-CSF: granulocyte-macrophage colony-stimulating factor. Holger Müller-Redetzky et al. Eur Respir Rev 2015;24:516-524 ©2015 by European Respiratory Society