Antiproteinase 3- and antimyeloperoxidase-associated vasculitis

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Presentation transcript:

Antiproteinase 3- and antimyeloperoxidase-associated vasculitis Casper F.M. Franssen, Coen A. Stegeman, Cees G.M. Kallenberg, Reinold O.B. Gans, Paul E. De Jong, Steven J. Hoorntje, Jan Willem Cohen Tervaert Kidney International Volume 57, Issue 6, Pages 2195-2206 (June 2000) DOI: 10.1046/j.1523-1755.2000.00080.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Doubling of serum creatinine within a certain time interval prior to the start of treatment in antiproteinase-3 (anti-PR3; ▪, N = 38) and antimyeloperoxidase (anti-MPO)–positive (, N = 31) patients with renal involvement. The numbers on top of the bars denote the percentage of the total number of patients with that particular antibody. Reprinted from Franssen et al92; used with permission from the International Society of Nephrology. Kidney International 2000 57, 2195-2206DOI: (10.1046/j.1523-1755.2000.00080.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Doubling of serum creatinine within a certain time interval prior to the start of treatment in antiproteinase-3 (anti-PR3; ▪, N = 38) and antimyeloperoxidase (anti-MPO)–positive (, N = 31) patients with renal involvement. The numbers on top of the bars denote the percentage of the total number of patients with that particular antibody. Reprinted from Franssen et al92; used with permission from the International Society of Nephrology. Kidney International 2000 57, 2195-2206DOI: (10.1046/j.1523-1755.2000.00080.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Superoxide release measured by ferricytochrome c reduction using tumor necrosis factor-α (TNF-α)–primed neutrophils from a healthy donor. Neutrophils were stimulated with immunoglobulin G fractions from anti-PR3 (▪, N = 17) and anti-MPO–positive patients (▵, N = 14) and from healthy controls (•, N = 16). Immunoglobulin G fractions from the ANCA-positive patients were obtained during active vasculitis prior to the start of immunosuppressive treatment. Data are mean values ± SEM. The dashed line indicates the release of reactive oxygen radicals induced by fMLP. Reprinted from Franssen et al122; used with permission from the American Society of Nephrology. Kidney International 2000 57, 2195-2206DOI: (10.1046/j.1523-1755.2000.00080.x) Copyright © 2000 International Society of Nephrology Terms and Conditions