The hallmarks of osteoarthritis and the potential to develop personalised disease- modifying pharmacological therapeutics D.P. Tonge, M.J. Pearson, S.W.

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The hallmarks of osteoarthritis and the potential to develop personalised disease- modifying pharmacological therapeutics D.P. Tonge, M.J. Pearson, S.W. Jones Osteoarthritis and Cartilage Volume 22, Issue 5, Pages 609-621 (May 2014) DOI: 10.1016/j.joca.2014.03.004 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representation of the multiple biological effect areas within the OA joint and key pathways to exploit for the development of pharmacological DMOADs. OA is widely recognised as a disease of the whole joint (encompassing cartilage, subchondral bone, synovium, skeletal muscle and adipose tissue), offering new opportunities to identify new drug targets, new drug combinations and re-profiling old drugs from other therapeutic areas. Osteoarthritis and Cartilage 2014 22, 609-621DOI: (10.1016/j.joca.2014.03.004) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions