Cerebral microdialysis: research technique or clinical tool

Slides:

Advertisements

Similar presentations

Human factors in anaesthesia: lessons from aviation

Advertisements

Touch contamination levels during anaesthetic procedures and their relationship to hand hygiene procedures: a clinical audit A.F. Merry, T.E. Miller,

Sun D. A. , Warriner C. B. , Parsons D. G. , Klein R. , Umedaly H. S

Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane R.I. Westphalen,

M. Lundblad, S. Kapral, P. Marhofer, P.-A. Lönnqvist

Supplemental oxygen and surgical site infection: getting to the truth

The effect of bi-level positive airway pressure mechanical ventilation on gas exchange during general anaesthesia Yu G , Yang K , Baker A.B. , Young.

The entrapped central venous catheter

Parkinson's disease and anaesthesia

A different use of visual analytic techniques in anaesthetics

M. Boutonnet, V. Faitot, A. Katz, L. Salomon, H. Keita

Protecting the brain and spinal cord

Mind the gap when performing emergency front-of-neck access

Prediction of volatile anaesthetic solubility in blood and priming fluids for extracorporeal circulation R.-G. Yu, J.-X. Zhou, J Liu British Journal.

A.F. Kalmar, J Van Aken, J Caemaert, E.P. Mortier, M.M.R.F. Struys

Acute toxic effects of ‘Ecstasy’ (MDMA) and related compounds: overview of pathophysiology and clinical management A.P. Hall, J.A. Henry British Journal.

Inflating LMA with normal saline: 14 yr after

L.M. Ferguson, G.B. Drummond British Journal of Anaesthesia

Modification of tracheal tubes

A. S. Himebauch, W. N. Sankar, J. M. Flynn, M. T. Sisko, G. S

Tissue oxygenation response to mild hypercapnia during cardiopulmonary bypass with constant pump output O. Akça, D.I. Sessler, D. Delong, R. Keijner,

A. A. Klein, T. Collier, J. Yeates, L. F. Miles, S. N. Fletcher, C

Neuromuscular junction in health and disease

Pituitary disease and anaesthesia

V. De Santis, M. Singer British Journal of Anaesthesia

Premedication with controlled-release oxycodone does not improve management of postoperative pain after day-case gynaecological laparoscopic surgery

Psychology of pain British Journal of Anaesthesia

Do team processes really have an effect on clinical performance

Traumatic brain injury: intensive care management

Expertise in practice: an ethnographic study exploring acquisition and use of knowledge in anaesthesia A. Smith, D. Goodwin, M. Mort, C. Pope British.

Tote S.P. , Grounds R.M. British Journal of Anaesthesia

Anaesthetists’ non-technical skills

C. Boer, S.M. Bossers, N.J. Koning British Journal of Anaesthesia

G. Park, M. Lane, S. Rogers, P. Bassett British Journal of Anaesthesia

Isotonic crystalloid solutions: a structured review of the literature

Anaemia during critical illness

Magnesium sulphate as a technique of hypotensive anaesthesia

The output of two sevoflurane vaporizers in the presence of helium

Anaesthesia for awake craniotomy—evolution of a technique that facilitates awake neurological testing A. Sarang, J. Dinsmore British Journal of Anaesthesia

FastrachTM tubes: modifying the design for use with the LMA CTrachTM?

Distraction and interruption in anaesthetic practice

J.G. Hardman, J.S. Wills British Journal of Anaesthesia

Effects of tracheal tube orientation on the success of intubation through an intubating laryngeal mask airway: study in Mallampati class 3 or 4 patients

Β2 Adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats G.M.T. Hare, J.M.A. Worrall, A.J. Baker, E. Liu,

II. Should anaesthetists stop infusing isotonic saline?

Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat J.L. Martin, D. Ma, M. Hossain, J. Xu,

Absorption of carbon dioxide during laparoscopy in children measured using a novel mass spectrometric technique Pacilli M , Pierro A , Kingsley C , Curry.

J.-L. Vincent, M.M. Wilkes, R.J. Navickis

Teamwork, communication, and anaesthetic assistance in Scotland

Improvement of cerebral blood flow patterns in hepatorenal syndrome using sustained low-efficiency dialysis S Bandyopadhyay, D Jakobson, K.D. Chhabra,

Large volume N2O uptake alone does not explain the second gas effect of N2O on sevoflurane during constant inspired ventilation† J.F.A. Hendrickx, R.

J.E. Spiegel, A. Vasudevan, Y. Li, P.E. Hess

J Lee, S Gupta, C Price, A.P. Baranowski

Enhanced upper respiratory tract airflow and head fanning reduce brain temperature in brain-injured, mechanically ventilated patients: a randomized, crossover,

Ventilation with the Ventrain through a small lumen catheter in the failed paediatric airway: two case reports M.G.A. Willemsen, R. Noppens, A.L.M. Mulder,

Trends in monitoring patients with aneurysmal subarachnoid haemorrhage

Repositioning a displaced tracheostomy tube with an Aintree intubation catheter mounted on a fibre-optic bronchoscope R. Rajendram, N. McGuire British.

Initiation of high-frequency oscillatory ventilation and its effects upon cerebral circulation in pigs: an experimental study M. David, K. Markstaller,

Incidence of adrenal insufficiency after severe traumatic brain injury varies according to definition used: clinical implications† F Bernard, J Outtrim,

Haemodynamic effects of oxytocin given as i. v

M. A. Yousef, S. Vaida, M. Somri, J. Mogilner, A. Lanir, A. Tamir, R

M.M. Tisdall, M. Smith British Journal of Anaesthesia

J.G. Laffey, é. Tobin, J.F. Boylan, A.J. McShane

Fibrinogen plasma concentration before delivery is not associated with postpartum haemorrhage: a prospective observational study O. Karlsson, A. Jeppsson,

H. Prabhakar, P.K. Bithal, I. Ghosh, H.H. Dash

Effects of temperature gradient correction of carbon dioxide absorbent on carbon dioxide absorption† G. Hirabayashi, H. Uchino, T. Sagara, T. Kakinuma,

Another case of obstruction to an anaesthetic circuit

D.A. Rowney, R. Fairgrieve, B. Bissonnette

D Frasca, C Dahyot-Fizelier, W Couet, B Debaene, O Mimoz, S Marchand

S. Das Adhikary, T. Venkatesan, S. Mohanty, M. Ponniah

Presentation transcript:

Cerebral microdialysis: research technique or clinical tool Tisdall M.M. , Smith M British Journal of Anaesthesia Volume 97, Issue 1, Pages 18-25 (July 2006) DOI: 10.1093/bja/ael109 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 1 Components of clinical MD catheter. 1, pump connector; 2, inlet tube; 3, MD catheter; 4, MD membrane; 5, outlet tube; 6, microvial holder; 7, microvial for collection of microdialysate. British Journal of Anaesthesia 2006 97, 18-25DOI: (10.1093/bja/ael109) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 2 Schematic representation of MD catheter in brain tissue. Fluid isotonic to the brain ECF is pumped through the MD catheter at a rate of 0.3 µl min−1. Molecules at high concentration in the brain ECF equilibrate across the semi-permeable MD membrane and can be analysed in the collected perfusate (the microdialysate). British Journal of Anaesthesia 2006 97, 18-25DOI: (10.1093/bja/ael109) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 3 Schematic representation of relationship between blood capillary and MD catheter in brain tissue. The MD catheter acts as an artificial blood capillary and the concentration of substrate in the collected fluid (microdialysate) is related to the balance between substrate delivery to, and uptake/excretion from, the ECF. British Journal of Anaesthesia 2006 97, 18-25DOI: (10.1093/bja/ael109) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 4 Changes in LPR in ‘at-risk’ (a) and normal (b) brain during a period of low and normal CPP. The normal range for LPR is shown by the shaded area. Note the increase in LPR in the ‘at-risk’ tissue during a period of cerebral hypoperfusion with normal values measured by the catheter in normal brain. British Journal of Anaesthesia 2006 97, 18-25DOI: (10.1093/bja/ael109) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions