Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change? D.J. Hunter, L. Li, Y.Q. Zhang, S. Totterman,

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Presentation transcript:

Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change? D.J. Hunter, L. Li, Y.Q. Zhang, S. Totterman, J. Tamez, C.K. Kwoh, C.B. Eaton, M.-P. Hellio Le Graverand, C.R. Beals Osteoarthritis and Cartilage Volume 18, Issue 2, Pages 175-183 (February 2010) DOI: 10.1016/j.joca.2009.08.002 Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 MRI slices and schematics depicting cartilage regions. Top panel Lateral sagittal depiction of femoral and tibial regions. Middle panel. Medial sagittal depiction of femoral and tibial regions. Lower panel. Coronal depiction of femoral and tibial regions including notch and spine. Osteoarthritis and Cartilage 2010 18, 175-183DOI: (10.1016/j.joca.2009.08.002) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Figure depicting denuded areas from a representative DESS image. The denuded areas are computed from the 3D rendering of the knee bones. The distal femur is displayed showing the denuded areas in red and the cartilage bone interface in grey (courtesy of VirtualScopics). Osteoarthritis and Cartilage 2010 18, 175-183DOI: (10.1016/j.joca.2009.08.002) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Trimming. The computer automatically creates an edge template to consistently remove from both time points at most 1.0mm from the edges of the cartilage tissue. Top, the red contours represent the cartilage tissue removed from the segmentation map. Bottom, 3D rendering of the removed tissue overplayed on top the 3D rendering of the femoral cartilage. Osteoarthritis and Cartilage 2010 18, 175-183DOI: (10.1016/j.joca.2009.08.002) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions