Long-term results 8 years after autologous osteochondral transplantation: 7 T gagCEST and sodium magnetic resonance imaging with morphological and clinical.

Slides:

Advertisements

Similar presentations

Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.

Advertisements

The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis Ms L. Torres, B.A., Dr D.D. Dunlop, Ph.D., Dr C.

T. Virén, M. Timonen, H. Tyrväinen, V. Tiitu, J.S. Jurvelin, J. Töyräs

IκB kinase inhibition as a potential treatment of osteoarthritis – results of a clinical proof- of-concept study K. Grothe, K. Flechsenhar, T. Paehler,

Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineering J.K. Mouw, M.S., N.D. Case, Ph.D., R.E. Guldberg,

A. Guermazi, H. Alizai, M. D. Crema, S. Trattnig, R. R. Regatte, F. W

T1ρ relaxation time of the meniscus and its relationship with T1ρ of adjacent cartilage in knees with acute ACL injuries at 3T R.I. Bolbos, Ph.D., T.M.

A. Watanabe, C. Boesch, S.E. Anderson, W. Brehm, P. Mainil Varlet

Mesenchymal stromal cells for cartilage repair in osteoarthritis

Multimodal approach in the use of clinical scoring, morphological MRI and biochemical T2-mapping and diffusion-weighted imaging in their ability to assess.

Dr L. S. Kim, N. D. , Dr L. J. Axelrod, N. D. , Dr P. Howard, M. D

T. Virén, M. Timonen, H. Tyrväinen, V. Tiitu, J.S. Jurvelin, J. Töyräs

The epidemiology and impact of pain in osteoarthritis

Evaluation of native hyaline cartilage and repair tissue after two cartilage repair surgery techniques with 23Na MR imaging at 7 T: initial experience

Evaluation of cartilage matrix disorders by T2 relaxation time in patients with hip dysplasia T. Nishii, M.D., H. Tanaka, M.D., N. Sugano, M.D., T. Sakai,

MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers Garry E. Gold, Deborah Burstein, Bernard Dardzinski, Phillip.

P.-S. Hsu, H.-H. Lin, C.-R. Li, W.-S. Chung

Osteoarthritis and Cartilage

Gene expression and cell differentiation in matrix-associated chondrocyte transplantation grafts: a comparative study C. Albrecht, B. Tichy, S. Nürnberger,

Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters A. Hanifi, J.B. Richardson,

Facet tropism and facet joint orientation: risk factors for the development of early biochemical alterations of lumbar intervertebral discs C. Schleich,

Transplantation of autologous endothelial progenitor cells in porous PLGA scaffolds create a microenvironment for the regeneration of hyaline cartilage.

S. Gavard Osteoarthritis and Cartilage

Statistical evaluation of biomedical studies

Bone marrow lesions on magnetic resonance imaging in hand osteoarthritis are associated with pain and interact with synovitis R. Liu, W. Damman, M. Reijnierse,

Evaluation of cartilage repair in the distal femur after autologous chondrocyte transplantation using T2 relaxation time and dGEMRIC J.E. Kurkijärvi,

Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality E.J. Koay, Ph.D.,

Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials M. Fransen, S.

Bilateral cartilage T2 mapping 9 years after Mega-OATS implantation at the knee: a quantitative 3T MRI study P.M. Jungmann, P.U. Brucker, T. Baum, T.M.

Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives Y. Henrotin Osteoarthritis and Cartilage

Accuracy and test–retest precision of quantitative cartilage morphology on a 1.0T peripheral magnetic resonance imaging system D. Inglis, Ph.D., M. Pui,

Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis M. Hasegawa, M.D.,

Transdermal buprenorphine plus oral paracetamol vs an oral codeine-paracetamol combination for osteoarthritis of hip and/or knee: a randomised trial

Comparison of the Usefulness of Laser-induced Photoacoustic Measurement & Magnetic Resonance Imaging (T2 Mapping, Diffusion Tensor Imaging) for Assessing.

The differences on extracellular matrix among each portion of meniscus

Efficacy and safety of intraarticular hyaluronic acid in the treatment of hip osteoarthritis: a systematic review J.C. Fernández López, M.D., Ph.D.,

A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation H.S. McCarthy,

Time to be positive about negative data?

J. Avouac, M.D., L. Gossec, M.D., M. Dougados, M.D.

Stem cell therapy for human cartilage defects: a systematic review

S. Sonne-Holm, M.D., Dr. Sci., S. Jacobsen, M.D.

J. Ranstam Osteoarthritis and Cartilage

Morphological and compositional monitoring of a new cell-free cartilage repair hydrogel technology – GelrinC by MR using semi-quantitative MOCART scoring.

Clinically important body weight gain following total hip arthroplasty: a cohort study with 5-year follow-up D.L. Riddle, J.A. Singh, W.S. Harmsen, C.D.

Osteoarthritis of the knee after meniscal resection: long term radiographic evaluation of disease progression P.T. Paradowski, L.S. Lohmander, M. Englund

Utilization rates of hip arthroplasty in OECD countries

Degeneration of patellar cartilage in patients with recurrent patellar dislocation following conservative treatment: evaluation with delayed gadolinium-enhanced.

A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading H.E. Kloefkorn, B.Y. Jacobs,

Who should have a joint replacement? A plea for more ‘phronesis’

Scaffold degradation elevates the collagen content and dynamic compressive modulus in engineered articular cartilage K.W. Ng, Ph.D., L.E. Kugler, B.S.,

Structural Damage of the Thumb Base in Patients With Hand Osteoarthritis, Assessment by Magnetic Resonance Imaging Compared to Standard Radiography S.

IκB kinase inhibition as a potential treatment of osteoarthritis – results of a clinical proof- of-concept study K. Grothe, K. Flechsenhar, T. Paehler,

T2 assessment and clinical outcome following autologous matrix-assisted chondrocyte and osteochondral autograft transplantation G.M. Salzmann, J. Paul,

D.J. Hunter Osteoarthritis and Cartilage

C. Ratzlaff, M. Koehoorn, J. Cibere, J. Kopec

Comparison of the extent to which total hip and total knee arthroplasty restore patient- reported physical function N.A. Glass, N.A. Segal, J.J. Callaghan,

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

N. Frey, T. Hügle, S.S. Jick, C.R. Meier, J. Spoendlin

Osteoarthritis year 2012 in review: biology

Location-specific hip joint space width for progression of hip osteoarthritis – Data from the Osteoarthritis Initiative C. Ratzlaff, C. Van Wyngaarden,

G. Blumenkrantz, B. S. , R. Stahl, M. D. , J. Carballido-Gamio, Ph. D

Systematic review of the impact of osteoarthritis on health outcomes for comorbid disease in older people L. Parkinson, D.L. Waters, L. Franck Osteoarthritis.

Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla S. Apprich, G.H.

Facet tropism and facet joint orientation: risk factors for the development of early biochemical alterations of lumbar intervertebral discs C. Schleich,

Cartilage repair of the ankle: first results of T2 mapping at 7

Osteoarthritis year in review 2016: mechanics

Examining a whole-organ magnetic resonance imaging scoring system for osteoarthritis of the knee using Rasch analysis P.G. Conaghan, M.B.B.S., Ph.D.,

M. Doherty, P. Dieppe Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Presentation transcript:

Long-term results 8 years after autologous osteochondral transplantation: 7 T gagCEST and sodium magnetic resonance imaging with morphological and clinical correlation I. Krusche-Mandl, B. Schmitt, L. Zak, S. Apprich, S. Aldrian, V. Juras, K.M. Friedrich, S. Marlovits, M. Weber, S. Trattnig Osteoarthritis and Cartilage Volume 20, Issue 5, Pages 357-363 (May 2012) DOI: 10.1016/j.joca.2012.01.020 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 It shows patient two, 9.4 years after ACT at the MFC. (A): Morphologic proton-density (PDw) FSE image. (B): Graphical overlay with T2 map. Colorbar represents relaxation times in [ms] → higher values = more water, disturbed collagen architecture. (C): Graphical overlay with gagCEST image. Colorbar represents gagCEST asymmetries in [%] → lower values, less PG content. (D): Graphical overlay with sodium image. Colorbar represents the sodium SNR values → lower values, less PG content. Osteoarthritis and Cartilage 2012 20, 357-363DOI: (10.1016/j.joca.2012.01.020) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 T2 relaxation times measured in repair and native cartilage of patients. All patients exhibited higher T2 values in the repair tissue, which is a sign of increased relative water content as well as an impairment of the collagen matrix structure. Osteoarthritis and Cartilage 2012 20, 357-363DOI: (10.1016/j.joca.2012.01.020) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 gagCEST asymmetry values measured in repair tissue and native tissue of patients. Native tissue exhibited higher values in all patients indicating increased cartilage GAG content compared to repair tissue. Osteoarthritis and Cartilage 2012 20, 357-363DOI: (10.1016/j.joca.2012.01.020) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Sodium SNR values measured in repair tissue and native tissue of patients. Similarly to gagCEST, native tissue exhibited higher values in all patients also indicating higher GAG content compared to repair tissue. Osteoarthritis and Cartilage 2012 20, 357-363DOI: (10.1016/j.joca.2012.01.020) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 It shows patient five, 8 years after OCT at the MFC. (A): Morphologic proton-density (PDw) FSE image. (B): Graphical overlay with T2 map. Colorbar represents relaxation times in [ms] → higher values = more water, disturbed collagen architecture. (C): Graphical overlay with gagCEST image. Colorbar represents gagCEST asymmetries in [%] → lower values, less PG content. (D): Graphical overlay with sodium image. Colorbar represents the sodium SNR values → lower values, less PG content. Osteoarthritis and Cartilage 2012 20, 357-363DOI: (10.1016/j.joca.2012.01.020) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions