Comparison of three methodologies for the determination of pulmonary fungal burden in experimental murine aspergillosis D.C. Sheppard, K.A. Marr, D.N.

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Presentation transcript:

Comparison of three methodologies for the determination of pulmonary fungal burden in experimental murine aspergillosis D.C. Sheppard, K.A. Marr, D.N. Fredricks, L.Y. Chiang, T. Doedt, S.G. Filler Clinical Microbiology and Infection Volume 12, Issue 4, Pages 376-380 (April 2006) DOI: 10.1111/j.1469-0691.2005.01349.x Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Time course of fungal burden as determined by three methods. Results are presented as median ± interquartile range. *Significantly different (p < 0.05) from day 0 results by the Wilcoxon rank sum test. n = eight mice for each time-point. Clinical Microbiology and Infection 2006 12, 376-380DOI: (10.1111/j.1469-0691.2005.01349.x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Correlation of the results of tissue fungal burden determination by different methods. Top row–-quantitative PCRvs. quantitative culture; middle row–-galactomannan EIA vs. quantitative culture; bottom row–-galactomannan EIA vs. quantitative PCR. (A) Comparison of three methods immediately post-infection when organisms remain as conidia. n = eight mice. (B) Comparison at all later time-points when organisms have formed hyphae. *Significant (p < 0.05) correlation between results by the Spearman rank correlation test. n = 24 mice. Clinical Microbiology and Infection 2006 12, 376-380DOI: (10.1111/j.1469-0691.2005.01349.x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions