Ultra-Sensitive Copeptin and Cardiac Troponin in Diagnosing Non-ST-Segment Elevation Acute Coronary Syndromes—The COPACS Study Fabrizio Ricci, MD, Rosa.

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Ultra-Sensitive Copeptin and Cardiac Troponin in Diagnosing Non-ST-Segment Elevation Acute Coronary Syndromes—The COPACS Study Fabrizio Ricci, MD, Rosa Di Scala, MD, Cristiano Massacesi, MD, Marta Di Nicola, PhD, Gianni Cremonese, MD, Doranna De Pace, MD, Serena Rossi, MD, Irma Griffo, MD, Ivana Cataldo, PhD, Stefano Martinotti, MD, PhD, Domenico Rotondo, MD, Allan S. Jaffe, MD, Marco Zimarino, MD, PhD, Raffaele De Caterina, MD, PhD The American Journal of Medicine Volume 129, Issue 1, Pages 105-114 (January 2016) DOI: 10.1016/j.amjmed.2015.06.033 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Flow chart of the recruitment and selection process, with biomarker results on admission and adjudicated final diagnoses. The asterisk (*) indicates that in the subgroup of patients with non-ST-segment elevation myocardial infarction presenting with a discordant ultra-sensitive copeptin+/medium-sensitivity cardiac troponin I− pattern on admission, a third high-sensitivity cardiac troponin I sample at >6 hours was required to confirm the diagnosis of non-ST-segment elevation myocardial infarction in 3 patients. Cop-cTnI = copeptin cardiac troponin I; NCCP = noncoronary chest pain; NSTEMI = with non-ST-segment elevation myocardial infarction. The American Journal of Medicine 2016 129, 105-114DOI: (10.1016/j.amjmed.2015.06.033) Copyright © 2016 The Authors Terms and Conditions

Figure 2 Box-whisker graphs of ultra-sensitive copeptin levels in the groups with noncoronary chest pain and non–ST-segment elevation myocardial infarction. Box-whisker plots show the 25th and 75th percentile ranges (box) with 95% confidence intervals (whiskers) and median values (transverse lines in the box). Statistically significant differences were found between the 2 groups (P < .001, Mann–Whitney U test). NCCP = noncoronary chest pain; NSTEMI = non-ST-elevation myocardial infarction. The American Journal of Medicine 2016 129, 105-114DOI: (10.1016/j.amjmed.2015.06.033) Copyright © 2016 The Authors Terms and Conditions