A cross-sectional study of HIV-seropositive patients with varying degrees of proteinuria in South Africa T.M. Han, S. Naicker, P.K. Ramdial, A.G. Assounga

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A cross-sectional study of HIV-seropositive patients with varying degrees of proteinuria in South Africa T.M. Han, S. Naicker, P.K. Ramdial, A.G. Assounga Kidney International Volume 69, Issue 12, Pages 2243-2250 (June 2006) DOI: 10.1038/sj.ki.5000339 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Microalbuminuric patient: low-power view demonstrating dilated tubules (H+E, original magnification, × 120). Kidney International 2006 69, 2243-2250DOI: (10.1038/sj.ki.5000339) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Microalbuminuric patient: high-power view demonstrating dilated tubules lined by flattened epithelium, and containing pale eosinophilic luminal secretions (H+E, original magnification, × 480). Kidney International 2006 69, 2243-2250DOI: (10.1038/sj.ki.5000339) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 3 Microalbuminuric patient: low-power view demonstrating hypertrophied and dilated tubules (H+E, original magnification, × 120). Kidney International 2006 69, 2243-2250DOI: (10.1038/sj.ki.5000339) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 4 Microalbuminuric patient: high-power view demonstrating hypertrophied tubules lined by swollen epithelial cells with vacuolated or eosinophilic cytoplasm (H+E, original magnification, × 480). Kidney International 2006 69, 2243-2250DOI: (10.1038/sj.ki.5000339) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 5 Microalbuminuric patient: medium-power view demonstrating collapsing glomerulopathy with focal segmental glomerulonephritis (H+E, original magnification, × 240). Kidney International 2006 69, 2243-2250DOI: (10.1038/sj.ki.5000339) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 6 Microalbuminuric patient: focus of interstitial nephritis containing interstitial lymphocytes and plasma cells with associated tubular atrophy (H+E, original magnification, × 240). Kidney International 2006 69, 2243-2250DOI: (10.1038/sj.ki.5000339) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 7 HIVAN combined with membranous glomerulonephritis. (a) HIVAN (collapsing glomerulopathy) (arrow) (Jones' silver stain, original magnification, × 240). (b) High-power view of (a): membranous glomerulonephritis demonstrating spike formation (arrow) (Jones' silver stain, × 1200, oil emersion). Kidney International 2006 69, 2243-2250DOI: (10.1038/sj.ki.5000339) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 8 EM of Figure 7: ultrastructural examination demonstrating thickened basement membrane with subepithelial (black arrow) and intramembranous deposits (white arrow), and swollen podocytes and foot process fusion (bold arrow) (original magnification, × 64 000). Kidney International 2006 69, 2243-2250DOI: (10.1038/sj.ki.5000339) Copyright © 2006 International Society of Nephrology Terms and Conditions