Daniel B. Costa, MD, PhD, Susumu Kobayashi, MD, PhD

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Presentation transcript:

Acquired Resistance to the ALK Inhibitor Crizotinib in the Absence of an ALK Mutation Daniel B. Costa, MD, PhD, Susumu Kobayashi, MD, PhD Journal of Thoracic Oncology Volume 7, Issue 3, Pages 623-625 (March 2012) DOI: 10.1097/JTO.0b013e318241daab Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Sequence chromatograms of crizotinib-progressive tumor specimens. Representative sequences from cDNA isolated from a liver metastasis and malignant pleural effusion are shown. Nucleotide areas corresponding to previously reported anaplastic lymphoma kinase (ALK) mutations (L1152, C1156, F1174, and L1196) are highlighted in blue. No sequence variations were identified based on the ALK gene sequence (NM_004304.3; homo sapiens ALK mRNA). Journal of Thoracic Oncology 2012 7, 623-625DOI: (10.1097/JTO.0b013e318241daab) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions