Life-Threatening Chemotoxicity

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Presentation transcript:

Life-Threatening Chemotoxicity

Program Goals

Introduction

Tumor Lysis Syndrome

High-Dose MTX: Paradigm of Life-Threatening Chemotoxicity

HDMTX: Mechanism of Action

Uses of HDMTX

Toxicities Associated With HDMTX

HDMTX Toxicity: Risk Factors

HDMTX: Drug-Drug Interactions

Preventing HDMTX Toxicity

HDMTX: Dosing and Administration

LV Rescue

MTX Clearance

Case 1: Adult

Case 1: Adult (cont)

HDMTX: Management of Toxicity

Case 2: Adolescent

Case 3: Adolescent

Case 3: Adolescent (cont)

Glucarpidase: Mechanism of Action

HDMTX-Induced Renal Dysfunction: Effect of Early Intervention of Glucarpidase + LV

HDMTX: Multidisciplinary Care

HDMTX: Reinitiation After Toxicity

HDMTX: Reinitiation After Toxicity (cont)

Conclusions

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