Volume 71, Issue 11, Pages (June 2007)

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Volume 71, Issue 11, Pages 1148-1154 (June 2007) Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels Z. Moldoveanu, R.J. Wyatt, J.Y. Lee, M. Tomana, B.A. Julian, J. Mestecky, W.-Q. Huang, S.R. Anreddy, S. Hall, M.C. Hastings, K.K. Lau, W.J. Cook, J. Novak Kidney International Volume 71, Issue 11, Pages 1148-1154 (June 2007) DOI: 10.1038/sj.ki.5002185 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Serum levels of Gal-deficient IgA in IgAN patients and healthy controls. (a) HAA-IgA level (U/ml, see Materials and methods) in sera from IgAN patients and healthy controls. (b) Receiver operating characteristic curve for HAA-IgA levels. Area under the curve is 0.902. The arrows with numbers indicate key points: (1) HAA-IgA serum level 1076U/ml; sensitivity 0.765, specificity 0.900; (2) HAA-IgA serum level 1702U/ml; sensitivity 0.503, specificity 0.993; and (3) HAA-IgA serum level 1810U/ml; sensitivity 0.444, specificity 1.000. Kidney International 2007 71, 1148-1154DOI: (10.1038/sj.ki.5002185) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 Reactivity of HAA with serum IgA in ELISA and Western blot assays. ELISA data are expressed as HAA-IgA (U/mg IgA); Western blot data are the ratios of heavy-chain band densities for HAA-binding IgA and total IgA. Six samples with wide range of HAA-IgA reactivities were used. The inset shows the two extremes: a highly reactive sample and a modestly reactive sample. Kidney International 2007 71, 1148-1154DOI: (10.1038/sj.ki.5002185) Copyright © 2007 International Society of Nephrology Terms and Conditions