Influence of adrenal hyperandrogenism on the clinical and metabolic phenotype of women with polycystic ovary syndrome  Macarena Alpañés, M.D., Manuel Luque-Ramírez, M.D., Ph.D., M. Ángeles Martínez-García, Ph.D., Elena Fernández-Durán, B.S., Francisco Álvarez-Blasco, M.D., Ph.D., Héctor Francisco Escobar-Morreale, M.D., Ph.D.  Fertility and Sterility  Volume 103, Issue 3, Pages 795-801.e2 (March 2015) DOI: 10.1016/j.fertnstert.2014.12.105 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Influence of adrenal hyperandrogenism (AH) and obesity on indexes of glucose metabolism. Data are expressed as mean ± SD of the means and were submitted to a two-way general linear model introducing age as a covariate. The shaded areas represent the 95% confidence intervals of 147 healthy control subjects. To convert to SI units, multiply glucose by 0.0555 (results in nmol/L), insulin by 6.945 (results in pmol/L), and DHEAS by 0.002714 (results in μmol/L). AUC = area under the curve. PCOS = polycystic ovary syndrome. *P<.05 for the difference between AH-PCOS and non-AH-PCOS women. †P<.05 for the difference between obese and nonobese PCOS women. ‡P<.05 for the interaction between AH and obesity. Fertility and Sterility 2015 103, 795-801.e2DOI: (10.1016/j.fertnstert.2014.12.105) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Influence of adrenal hyperandrogenism and obesity on serum lipids. Data are expressed as mean ± SD of the means and were submitted to a two-way general linear model introducing age as a covariate. The shaded areas represent the 95% confidence intervals of 147 healthy control subjects. To convert to SI units, multiply cholesterol by 0.0259 (results in mmol/L), triglycerides by 0.0113 (results in mmol/L), and DHEAS by 0.002714 (results in μmol/L). HDL = high-density lipoprotein; LDL = low-density lipoprotein; other abbreviations as in Figure 1. †P<.05 for the difference between obese and nonobese PCOS women. ‡P<.05 for the interaction between AH and obesity. Fertility and Sterility 2015 103, 795-801.e2DOI: (10.1016/j.fertnstert.2014.12.105) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Influence of adrenal hyperandrogenism (AH) and obesity on systolic and diastolic blood pressure. Data are expressed as mean ± SD of the means and were submitted to a two-way general linear model introducing age as a covariate. The shaded areas represent the 95% confidence intervals of 147 healthy control subjects. To convert to SI units, multiply DHEAS by 0.002714 (results in μmol/L). PCOS = polycystic ovary syndrome. †P<.05 for the difference between obese and nonobese PCOS women. Fertility and Sterility 2015 103, 795-801.e2DOI: (10.1016/j.fertnstert.2014.12.105) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions