Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium K. Hegstad,

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Presentation transcript:

Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium K. Hegstad, T. Mikalsen, T.M. Coque, G. Werner, A. Sundsfjord Clinical Microbiology and Infection Volume 16, Issue 6, Pages 541-554 (June 2010) DOI: 10.1111/j.1469-0691.2010.03226.x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Schematic presentation of transposons from each of the three transposon groups transferring resistance genes in enterococci. aac6'-aph2″, aminoglycoside-6'-N-acetyltransferase-2″-Ophosphoryltrasferase;tnpA, transposase; tnpR, resolvase; vanA/vanB2 cluster, clusters conferring vancomycin resistance; tra region, region containing transfer genes; oriT, origin of transfer; xis, excisionase; int, integrase. Clinical Microbiology and Infection 2010 16, 541-554DOI: (10.1111/j.1469-0691.2010.03226.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Toxin–antitoxin (TA) pairs contribute efficiently to plasmid maintenance in a bacterial population. If TA-carrying plasmids are not inherited by the daughter cells after cell division, the less stable antitoxin is degraded by proteases and the toxin is left free to interact with its intracellular target, which leads to growth inhibition or cell death. Clinical Microbiology and Infection 2010 16, 541-554DOI: (10.1111/j.1469-0691.2010.03226.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions