Localized Amyloid Light-Chain Amyloidosis and Extramedullary Plasmacytoma of the Mitral Valve Aurélien Roumy, MD, Laurence de Leval, MD, Lars Niclauss,

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Presentation transcript:

Localized Amyloid Light-Chain Amyloidosis and Extramedullary Plasmacytoma of the Mitral Valve Aurélien Roumy, MD, Laurence de Leval, MD, Lars Niclauss, MD, Stephan C. Schaefer, MD, Paul Kurtin, MD, Ahmet Dogan, MD, PhD, Ludwig K. von Segesser, MD, Patrick Ruchat, MD The Annals of Thoracic Surgery Volume 95, Issue 5, Pages 1782-1784 (May 2013) DOI: 10.1016/j.athoracsur.2012.08.085 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Transesophageal echocardiography view of the posterior mitral valve leaflet. Arrow indicates mass of the tumor. The Annals of Thoracic Surgery 2013 95, 1782-1784DOI: (10.1016/j.athoracsur.2012.08.085) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Macroscopic view of the posterior mitral valve leaflet. The Annals of Thoracic Surgery 2013 95, 1782-1784DOI: (10.1016/j.athoracsur.2012.08.085) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Microscopic features of the nodules. (A) The nodules consisted of abundant extracellular amorphous eosinophilic material, associated with cellular clusters (hematoxylin and eosin, original magnification ×50). (B) The extracellular material produced a red birefringence under polarization after Congo red staining (original magnification ×400). (C) The cellular clusters consisted of aggregates of mature-appearing plasma cells (hematoxylin and eosin, original magnification ×400). (D) The plasma cells and the amyloid material did not stain for kappa light chains (immunoperoxidase, original magnification ×400), whereas (E) they positively stained for lambda light chains (immunoperoxidase, original magnification ×400). The Annals of Thoracic Surgery 2013 95, 1782-1784DOI: (10.1016/j.athoracsur.2012.08.085) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions