Diabetic glomerulopathy.

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Diabetic glomerulopathy. Diabetic glomerulopathy. Changes in glomerular histology in diabetic glomerulopathy (A) Normal glomerulus. (B) Diffuse mesangial expansion with mesangial cell proliferation. (C) Prominent mesangial expansion with early nodularity and mesangiolysis. (D) Accumulation of mesangial matrix forming Kimmelstiel–Wilson nodules. (E) Dilation of capillaries forming microaneurysms, with subintimal hyaline (plasmatic insudation). (F) Obsolescent glomerulus. A–D and F were stained with period acid–Schiff stain, and E was stained with Jones stain. Original magnification, ×400. Radica Z. Alicic et al. CJASN 2017;12:2032-2045 ©2017 by American Society of Nephrology