Ischemic preconditioning ameliorates spinal cord ischemia-reperfusion injury by triggering autoregulation Cheng-Loong Liang, MD, Kang Lu, MD, PhD, Po-Chou.

Slides:

Advertisements

Similar presentations

Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages (October 2014) DOI:

Advertisements

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Multidisciplinary care improves amputation-free survival in patients with chronic critical limb ischemia Jayer Chung, MD, J. Gregory Modrall, MD, Chul.

Without prejudice Journal of Vascular Surgery

Successful lower extremity angioplasty improves brachial artery flow-mediated dilation in patients with peripheral arterial disease Marc Husmann, MD,

Jeanwan Kang, MD, Hassan Albadawi, MD, Patrick J. Casey, MD, Thomas A

Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats

Early ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusion Ioannis K. Toumpoulis,

Superiority of early relative to late ischemic preconditioning in spinal cord protection after descending thoracic aortic occlusion Ioannis K. Toumpoulis,

Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia Enyi Shi, MD, PhD, Xiaojing.

Gale Tang, MD, David N. Charo, Rong Wang, PhD, Israel F

Risk factors and outcomes of postoperative ischemic colitis in contemporary open and endovascular abdominal aortic aneurysm repair Zhobin Moghadamyeghaneh,

DNA damage and repair system in spinal cord ischemia

Ischemic postconditioning protects the spinal cord from ischemia–reperfusion injury via modulation of redox signaling Wenying Song, MD, Jing Sun, MD,

Intrathecal transplantation of bone marrow stromal cells attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia-reperfusion injury.

Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice Bao-Ngoc Nguyen, MD, Hassan Albadawi, MD, Rahmi Oklu,

Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits Hironori Baba, MD, Yoshihisa Tanoue, MD, PhD, Taketoshi.

Loic Lang-Lazdunski, MDa,b. , Catherine Heurteaux, PhDb

The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model Yujiro Kawanishi, MD, Kenji Okada, MD, Hiroshi.

Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury Lihong Fan, MD, Kunzheng.

Cellular and molecular mechanism regulating blood flow recovery in acute versus gradual femoral artery occlusion are distinct in the mouse Yagai Yang,

Prevention of ischemic spinal cord injury: Comparative effects of magnesium sulfate and riluzole Loïc Lang-Lazdunski, MD, Catherine Heurteaux, PhD, Hervé.

Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion Patrick.

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats Loïc Lang-Lazdunski, MD, PhD, Nicolas Blondeau,

Revision using distal inflow is a safe and effective treatment for ischemic steal syndrome and pathologic high flow after access creation Thomas M. Loh,

The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation T.

Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease Alessandra Bitto, MD, Francesca Polito,

Cold spinoplegia and transvertebral cooling pad reduce spinal cord injury during thoracoabdominal aortic surgery Mitsuhiro Isaka, MD, Hajime Kumagai,

The neuroprotective effects of intrathecal administration of the selective N-type calcium channel blocker ziconotide in a rat model of spinal ischemia

Neuroprotection following mild hypothermia after spinal cord ischemia in rats Takeshi Saito, PhD, Shino Saito, MD, Hiroshi Yamamoto, MD, PhD, Masanori.

Long-term safety of cilostazol in patients with peripheral artery disease: The CASTLE study (Cilostazol: A Study in Long-term Effects) William R. Hiatt,

Using distal revascularization with interval ligation as the primary treatment of hand ischemia after dialysis access creation Rahim Aimaq, MD, Steven.

Long-term outcomes of internal carotid artery dissection

Without prejudice Journal of Vascular Surgery

Insulin-like growth factor 1 prevents neuronal cell death and paraplegia in the rabbit model of spinal cord ischemia Yoshihisa Nakao, MD, Hajime Otani,

The influence of the characteristics of ischemic tissue lesions on ulcer healing time after infrainguinal bypass for critical leg ischemia Maria Söderström,

Neuronal Cell Death in the Ischemic Spinal Cord: The Effect of Methylprednisolone Georgios K. Kanellopoulos, MD, Hiroyuki Kato, MD, PhD, Yingji Wu, MSc,

Interleukin-1 receptor antagonist attenuates the severity of spinal cord ischemic injury in rabbits Satoshi Akuzawa, MD, Teruhisa Kazui, MD, PhD, Enyi.

Autophagy-mediated stress response in motor neurons after hypothermic spinal cord ischemia in rabbits Satoshi Fujita, MD, Masahiro Sakurai, MD, PhD,

David A. Zvara, MD, David M. Colonna, MD, Dwight D. Deal, BS, Jason C

Denis W. Harkin, MD, Aires A. B

Dose-dependent neuroprotection of delta-opioid peptide [D-Ala2, D-Leu5] enkephalin on spinal cord ischemia-reperfusion injury by regional perfusion into.

Thrombolysis for lower extremity bypass graft occlusion

Survival and death-promoting events after transient spinal cord ischemia in rabbits: Induction of Akt and caspase3 in motor neurons Masahiro Sakurai,

A peroxisome proliferator-activated receptor gamma agonist attenuates neurological deficits following spinal cord ischemia in rats Hyunchang Kim, MD,

Ugursay Kiziltepe, MD, N. Nilufer D Turan, PhD, Unsal Han, MD, A

Trends in the incidence, treatment, and outcomes of acute lower extremity ischemia in the United States Medicare population Donald T. Baril, MD, Kaushik.

Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques Benjamin J. Dunmore, PhD, Mark J. McCarthy,

New method for absolute spinal cord ischemia protection in rabbits

Endoplasmic reticulum stress induced in motor neurons by transient spinal cord ischemia in rabbits Masahiro Sakurai, MD, PhD, Goro Takahashi, MD, PhD,

Karthikeshwar Kasirajan, MD, Mark D. Morasch, MD, Michel S

Autophagy-mediated stress response in motor neuron after transient ischemia in rabbits Hironori Baba, MD, Masahiro Sakurai, MD, PhD, Koji Abe, MD, PhD,

Reply Journal of Vascular Surgery

Todd R. Vogel, MD, MPH, Robin L. Kruse, PhD

Hypogastric and subclavian artery patency affects onset and recovery of spinal cord ischemia associated with aortic endografting Matthew J. Eagleton,

Naloxone lowers cerebrospinal fluid levels of excitatory amino acids after thoracoabdominal aortic surgery Takashi Kunihara, MD, PhD, Kenji Matsuzaki,

Thrombotic mesenteric ischemia due to aortic dissection

Daniel J. Martin, MD, Tomas D. Martin, MD, Philip J

Regarding “Lunar cycles and abdominal aortic aneurysm rupture”

Long-term prognostic factors after thrombolysis for lower limb ischemia Monica Kuoppala, MD, Sofia Franzén, MD, Bengt Lindblad, MD, PhD, Stefan Acosta,

Ischemia-reperfusion injury of the spinal cord: Protective effect of the hydroxyl radical scavenger dimethylthiourea Willem Wisselink, MD, Samuel R.

Gary W. Barone, MD, Axel W. Joob, MD, Terry L. Flanagan, MPH, Carey E

Avoiding reperfusion injury after limb revascularization: Experimental observations and recommendations for clinical application Friedhelm Beyersdorf,

Abdominal aortic aneurysm prefers to rupture on a dim day

Direct noninvasive monitoring of spinal cord motor function during thoracic aortic occlusion: Use of motor evoked potentials John C. Laschinger, M.D.,

Unusual aortic collapse in acute mesenteric ischemia

Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats Chih-Yang Chan, MD, Yih-Sharng Chen, MD,

J. David Neel, MD, Robin L. Kruse, PhD, Viktor Y

John F. Eidt, MD, Elliot Chaikof, MD, PhD, Anton N. Sidawy, MD, MPH

Presentation transcript:

Ischemic preconditioning ameliorates spinal cord ischemia-reperfusion injury by triggering autoregulation Cheng-Loong Liang, MD, Kang Lu, MD, PhD, Po-Chou Liliang, MD, Tai-Been Chen, PhD, Samuel H.H. Chan, PhD, Han-Jung Chen, MD, PhD Journal of Vascular Surgery Volume 55, Issue 4, Pages 1116-1123 (April 2012) DOI: 10.1016/j.jvs.2011.09.096 Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 1 Tarlov scores are represented in the four groups on days 1, 3, 5, and 7. Tarlov scores in the ischemia-reperfusion (I/R) group were significantly lower than those in the sham (S), ischemic preconditioning (P), and P+I/R groups (n = 6 in each group) on days 1, 3, 5, and 7. The error bars show the standard deviation. *P < .001. Journal of Vascular Surgery 2012 55, 1116-1123DOI: (10.1016/j.jvs.2011.09.096) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 2 Representative photomicrographs of lumbar spinal cord sections are stained by immunostaining with neuronal nuclear antigen in the sham (S), ischemia-reperfusion (I/R), ischemia preconditioning (P), and the P+I/R groups (n = 6 in each group). The numbers of survival motor neurons (red neuronal cell) in the four groups are shown on day 7 after reperfusion. *P < .001. Journal of Vascular Surgery 2012 55, 1116-1123DOI: (10.1016/j.jvs.2011.09.096) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 3 Spinal cord blood flow in the four groups is represented. The arrows indicate aortic occlusion and the arrowheads indicate release of aortic occlusion. A, Sham (S) and ischemic preconditioning (P) groups. *P < .001. **P = .001-.043. B, Ischemia-reperfusion (I/R) and P+I/R groups (n = 6 in each group). *P < .001. **P < .001. ***P = .016-.045. Journal of Vascular Surgery 2012 55, 1116-1123DOI: (10.1016/j.jvs.2011.09.096) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 4 Spinal cord tissue oxygenation in the four groups is represented. The arrows indicate aortic occlusion and the arrowheads indicate release of aortic occlusion. A, Sham (S) and ischemic preconditioning (P) groups. *P < .001. **P = .026-.043. ***P = .032-.043. B, Ischemia-reperfusion group (I/R) and P+I/R groups (n = 6 in each group). *P < .001. **P = .003-.004. ***P = .001-.038. Journal of Vascular Surgery 2012 55, 1116-1123DOI: (10.1016/j.jvs.2011.09.096) Copyright © 2012 Society for Vascular Surgery Terms and Conditions