Pain and the immune system

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Presentation transcript:

Pain and the immune system H.L. Rittner, A. Brack, C. Stein British Journal of Anaesthesia Volume 101, Issue 1, Pages 40-44 (July 2008) DOI: 10.1093/bja/aen078 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 Intracellular mechanisms of opioid peptide release from granulocytes. Opioid peptide-containing granulocytes migrate into inflamed tissue. Opioid peptides are released and bind to opioid receptors on peripheral sensory neurons leading to analgesia. CXCL2/3 produces antinociception by triggering opioid peptide release. CXCL2/3-induced opioid release requires elevation of intracellular Ca2+ via flux from the endoplasmatic reticulum (ER). In addition, activation of phosphoinositol-3-kinase (PI3K) and p38 mitogen-activated kinase (MAPK) are involved. PLC, phospholipase C; IP3, inositol 1,4,5-triphosphate. British Journal of Anaesthesia 2008 101, 40-44DOI: (10.1093/bja/aen078) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Effects of granulocyte depletion and reconstitution with adoptively transferred granulocytes on CXCL2/3-induced antinociception. Rats were pretreated with i.v. anti-granulocyte (polymorphonuclear cells) serum (grey bars); control animals received non-immune rabbit serum (white bars). Two hours after complete Freund’s adjuvant, the number of leucocytes in the paw (a) was quantified by flow cytometry. Paw pressure threshold (PPT) (b) was measured before (baseline) and after intraplantar injection of CXCL2/3. (c) Different numbers of allogenic glycogen-recruited peritoneal granulocytes from normal animals were injected into the inflamed paws of granulocyte-depleted rats. PPT was obtained 15 min later and again after intraplantar CXCL2/3 (white bar: before CXCL2/3 without granulocyte depletion; cross-hatched bar: effect of intraplantar CXCL2/3 without granulocyte depletion; grey bars: granulocyte depletion; striped bars: granulocyte reconstitution). (d) Effect of ex vivo BAPTA/AM (an intracellular calcium chelator) or solvent pre-treatment before allogenic granulocyte transfer. Rats were granulocyte-depleted and reconstituted as described in (c) using 1×106 granulocytes and CXCL2/3-induced PPT elevation was measured thereafter. *P<0.05. Data are means(sem). Reproduced with permission from Rittner and colleagues.32 British Journal of Anaesthesia 2008 101, 40-44DOI: (10.1093/bja/aen078) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions