Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines  Stephen M. Ansell, MD, PhD, Robert A. Kyle, MD, Craig B. Reeder, MD, Rafael Fonseca, MD, Joseph R. Mikhael, MD, William G. Morice, MD, PhD, P. Leif Bergsagel, MD, Francis K. Buadi, MD, Joseph P. Colgan, MD, David Dingli, MD, PhD, Angela Dispenzieri, MD, Philip R. Greipp, MD, Thomas M. Habermann, MD, Suzanne R. Hayman, MD, David J. Inwards, MD, Patrick B. Johnston, MD, Shaji K. Kumar, MD, Martha Q. Lacy, MD, John A. Lust, MD, PhD, Svetomir N. Markovic, MD, PhD, Ivana N.M. Micallef, MD, Grzegorz S. Nowakowski, MD, Luis F. Porrata, MD, Vivek Roy, MD, Stephen J. Russell, MD, PhD, Kristen E. Detweiler Short, RN, CNP, A. Keith Stewart, MD, Carrie A. Thompson, MD, Thomas E. Witzig, MD, Steven R. Zeldenrust, MD, PhD, Robert J. Dalton, MD, S. Vincent Rajkumar, MD, Morie A. Gertz, MD  Mayo Clinic Proceedings  Volume 85, Issue 9, Pages 824-833 (September 2010) DOI: 10.4065/mcp.2010.0304 Copyright © 2010 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 1 Mayo Clinic (Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy [mSMART]) consensus for management of newly diagnosed Waldenström macroglobulinemia (WM). MGUS = monoclonal gammopathy of undetermined significance. SI conversion factor: To convert hemoglobin values to g/L, multiply by 10. Mayo Clinic Proceedings 2010 85, 824-833DOI: (10.4065/mcp.2010.0304) Copyright © 2010 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 2 Mayo Clinic (Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy [mSMART]) consensus for management of relapsed Waldenström macroglobulinemia. Mayo Clinic Proceedings 2010 85, 824-833DOI: (10.4065/mcp.2010.0304) Copyright © 2010 Mayo Foundation for Medical Education and Research Terms and Conditions