Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk E.Jan Irvine, John K. Marshall Gastroenterology

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Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk E.Jan Irvine, John K. Marshall Gastroenterology Volume 119, Issue 6, Pages 1740-1744 (December 2000) DOI: 10.1053/gast.2000.20231 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 (A) Single- and (B) double-contrast views of the terminal ileum of the patient at age 21 show several features of Crohn's ileitis: separation of loops (short arrows), antimesenteric scalloping (long arrows), stricture with linear ulceration (curved arrow), and an ulceronodular mucosal relief pattern (open arrow). Gastroenterology 2000 119, 1740-1744DOI: (10.1053/gast.2000.20231) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Intestinal permeability of the study cohort. Results are expressed as the percentage of an oral dose of 51Cr-EDTA excreted in the urine over 24 hours (upper limit of normal, 2.3%). The urinary excretion value for the index case is highlighted (arrow). Gastroenterology 2000 119, 1740-1744DOI: (10.1053/gast.2000.20231) Copyright © 2000 American Gastroenterological Association Terms and Conditions