Bone 2014;61:191 (Fig. 2) Reproduced from Bone, 61:191-200, Copyright (2014), with permission from Elsevier.

Inner Transitional Zone Compact cortex Outer transitional zone Trabecular Compartment Inner Transitional Zone Bone 2014;59:173 (Fig. 2) Reproduced from Bone, 59:173-9, Copyright (2014), with permission from Elsevier. –2.0 –1.0 0.0 1.0 6 12 a,c a,b,c,d b a –1.5 –1.0 –0.5 0.0 0.5 6 12 a,c a,b,c,d a,b –1.5 –1.0 –0.5 0.0 0.5 6 12 a,b,c,d a,c 0.3 0.2 0.1 0.0 –0.1 6 12 a a,c a,b,c a,b c

* * * * * Trabecular Bone Cortical Bone Haversian canal remodeling 8 4 ng/mg dry weight Ibandronate concentration L6 Vert total prox diaph distal Cortical Bone Haversian canal remodeling Active area Labelled surf (mm2) (%) Tibia cortical bone 8 4 0.4 0.2 1.0 0.5 Trabecular Bone MS/BS (%) BFR/BV mm2/mm2/yr AF (/yr) 0.4 0.2 0.0 4 2 * * * Mean (SD) Adapted from Bone, 31:45-55, Copyright (2003), with permission from Elsevier. 2000 1000 Ultimate load (N) Femoral Neck Endoortical surface MS/BS (%) 16 8 * 2000 1000 Ultimate load (N) Vertebrae * 3

J Bone Miner Res 2014;doi:10.1002/jbmr.2211 (Fig. 1) Reproduced from J Bone Miner Res 2014;doi:10.1002/jbmr.2211 with permission of the American Society of Bone and Mineral Research.

J Bone Miner Res 2014;doi:10.1002/jbmr.2211 (Fig. 3) Reproduced from J Bone Miner Res 2014;doi:10.1002/jbmr.2211 with permission of the American Society of Bone and Mineral Research.

J Bone Miner Res 2014;doi:10.1002/jbmr.2194 (Figs. 2, 5) Reproduced from J Bone Miner Res 2014;doi:10.1002/jbmr.2194 with permission of the American Society of Bone and Mineral Research.

Osteoporos Int 2014;25:367 (Fig. 2) Reproduced from Osteoporos Int 2014;25:367-76 with permission from Springer.

Osteoporos Int 2014;25:367 (Figs. 3, 4) Reproduced from Osteoporos Int 2014;25:367-76 with permission from Springer.

Earlier Postmenopause Premenopause Earlier Postmenopause Later Postmenopause Placebo Risedronate Risedronate % Change Controls Risedronate 5 4 3 2 1 -1 -2 ** * CC OTZ trabecular Porosity vBMD % Change 1 0.5 -0.5 -1.0 Controls Risedronate *,** * CC OTZ trabecular Porosity vBMD Adapted from J Bone Miner Res 2014;29:380-8 with permission of the American Society of Bone and Mineral Research.

J Bone Miner Res 2014;29:166 (Figs. 2, 3) Reproduced from J Bone Miner Res 2014;29:166-72 with permission of the American Society of Bone and Mineral Research.

Osteoporos Int 2014;25:1163 (Fig. 1) Reproduced from Osteoporos Int 2014;25:1163-72 with permission from Springer.

Osteoporos Int 2014;25:1163 (Figs. 2, 3) Reproduced from Osteoporos Int 2014;25:1163-72 with permission from Springer.

J Bone Miner Res 2014;doi:10.1002/jbmr.2188 (Fig. 4) Reproduced from J Bone Miner Res 2014;doi:10.1002/jbmr.2188 with permission of the American Society of Bone and Mineral Research.

Bone 2014;61:149 (Fig. 2) Reproduced from Bone, 61:149-57, Copyright (2014), with permission from Elsevier.

Bone 2014;61:149 (Fig. 4) Reproduced from Bone, 61:149-57, Copyright (2014), with permission from Elsevier.

Bone 2014;59:139 (Fig. 3) Reproduced from Bone, 59:139-47, Copyright (2014), with permission from Elsevier.