IgG4-related tubulointerstitial nephritis

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IgG4-related tubulointerstitial nephritis Lynn D. Cornell Kidney International Volume 78, Issue 10, Pages 951-953 (November 2010) DOI: 10.1038/ki.2010.342 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Classification of tubulointerstitial nephritis/nephropathy. Tubulointerstitial nephritis/nephropathy cases can be placed into different etiologic categories, with the approximate relative prevalence on renal biopsy represented here by the size of each bubble. Tubulointerstitial nephritis (TIN) associated with systemic IgG4-related disease is an autoimmune TIN that usually has tubular basement membrane (TBM) and interstitial immune complex deposits. TBM deposits are an unusual feature in the absence of glomerular immune deposits, and their presence can help categorize a TIN. Sometimes overlap between etiologic categories exists: for example, some cases of BK polyomavirus infection show TBM immune complex deposits that stain for IgG and C4d, which may indicate an additional autoimmune reaction; and some cases of methicillin-induced TIN have anti-TBM antibodies. NSAID, nonsteroidal anti-inflammatory drug; TINU, tubulointerstitial nephritis with uveitis. Kidney International 2010 78, 951-953DOI: (10.1038/ki.2010.342) Copyright © 2010 International Society of Nephrology Terms and Conditions