Innate Immune DNA-Sensing Pathways

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Presentation transcript:

Innate Immune DNA-Sensing Pathways Cell Volume 152, Issue 3, (January 2013) DOI: 10.1016/j.cell.2013.01.026 Copyright © 2013 Terms and Conditions

cGAS interacts with DNA in the cytosol. Image courtesy of Zhijian Chen. Cell 2013 152, DOI: (10.1016/j.cell.2013.01.026) Copyright © 2013 Terms and Conditions

In phagocytes, the TLR9-UNC93B complex (yellow) migrates to engulfed DNA-IgG-coated beads. Image courtesy of Miguel Sanjuanm. Cell 2013 152, DOI: (10.1016/j.cell.2013.01.026) Copyright © 2013 Terms and Conditions

TRIM21 negatively regulates DDX41-dependent innate responses to DNA viruses. Image courtesy of iStock/Henrik5000. Cell 2013 152, DOI: (10.1016/j.cell.2013.01.026) Copyright © 2013 Terms and Conditions

Trex1 deficiency causes an expanded lysosomal compartment in fibroblasts. Image courtesy of Nan Yan. Cell 2013 152, DOI: (10.1016/j.cell.2013.01.026) Copyright © 2013 Terms and Conditions